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Jablonski KL, Devore MD, Ryan MA, et al. Pharmacologic Therapy for Posttraumatic Stress Disorder: Review of Prescriptions and Potential Drug-Drug Interactions in a Military Cohort. Prim Care Companion CNS Disord. 2015;17(6)doi: 10.4088/PCC.15m01843.
Jablonski, K. L., Devore, M. D., Ryan, M. A., Streeter, E. L., Tolentino, J. C., Klinski, A. A., & Bahlawan, N. (2015). Pharmacologic Therapy for Posttraumatic Stress Disorder: Review of Prescriptions and Potential Drug-Drug Interactions in a Military Cohort. The primary care companion for CNS disorders, 17(6), . https://doi.org/10.4088/PCC.15m01843
Jablonski, Kara L, et al. "Pharmacologic Therapy for Posttraumatic Stress Disorder: Review of Prescriptions and Potential Drug-Drug Interactions in a Military Cohort." The primary care companion for CNS disorders vol. 17,6 (2015). doi: https://doi.org/10.4088/PCC.15m01843
Jablonski KL, Devore MD, Ryan MA, Streeter EL, Tolentino JC, Klinski AA, Bahlawan N. Pharmacologic Therapy for Posttraumatic Stress Disorder: Review of Prescriptions and Potential Drug-Drug Interactions in a Military Cohort. Prim Care Companion CNS Disord. 2015 Dec 03;17(6). doi: 10.4088/PCC.15m01843. eCollection 2015. PMID: 27057415; PMCID: PMC4805416.
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Prim Care Companion CNS Disord. 2015 Dec 03;17(6). doi: 10.4088/PCC.15m01843. eCollection 2015.

Pharmacologic Therapy for Posttraumatic Stress Disorder: Review of Prescriptions and Potential Drug-Drug Interactions in a Military Cohort.

The primary care companion for CNS disorders

Kara L Jablonski, Maria D Devore, Margaret A Ryan, Emily L Streeter, Jerlyn C Tolentino, Angelica A Klinski, Nahed Bahlawan

Affiliations

  1. Department of Pharmacy, Naval Hospital Camp Pendleton, Camp Pendleton, California.
  2. Clinical Investigations Department, Naval Hospital Camp Pendleton, Camp Pendleton, California.
  3. CDR, USPHS; Treatment Programs Department, Naval Hospital Camp Pendleton, Camp Pendleton, California.
  4. CDR, MSC, USN; Department of Pharmacy, Naval Hospital Camp Pendleton, Camp Pendleton, California.

PMID: 27057415 PMCID: PMC4805416 DOI: 10.4088/PCC.15m01843

Abstract

OBJECTIVE: To describe outpatient prescription treatment for active-duty military members with posttraumatic stress disorder (PTSD). Medical records were screened for drug-drug interactions with PTSD-related medications and for adverse drug events.

METHOD: A retrospective chart review was conducted of the medical records of active-duty service members aged 18 to 65 years who had a diagnosis of PTSD (ICD-9 criteria) and received psychiatric treatment at Naval Hospital Camp Pendleton, Camp Pendleton, California, between October 1, 2010, and October 31, 2010. Prescription medication treatment over a 6-month period (October 1, 2010, through March 31, 2011) was reviewed.

RESULTS: Among 275 patients, 243 (88.4%) had at least 1 prescription dispensed and 219 (79.6%) had at least 1 PTSD-related medication dispensed. More than 1 PTSD-related medication was dispensed to 153 (55.6%) patients. The most common medication classes dispensed were selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) (35.1%), novel antidepressants (15.6%), and anticonvulsants (15.0%). The most frequently dispensed PTSD-related medications were zolpidem: 149 (9.8%), sertraline: 147 (9.7%), gabapentin: 134 (8.8%), prazosin: 111 (7.3%), and trazodone: 110 (7.2%). In the subgroup of 219 patients who received PTSD-related medications, overlapping periods of treatment between an SSRI and another PTSD-related medication occurred in 58 (26.5%) patients. Potential drug-drug interactions with this combination involved 44 (20.1%) patients; no adverse drug events were reported. Among these 44 patients, 55 different potential drug-drug interactions were identified.

CONCLUSIONS: Patients receiving medications for PTSD are frequently treated with SSRIs or SNRIs and are likely to be prescribed more than 1 PTSD-related medication.

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