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Schönberg K, Rudolph J, Yajnanarayana SP, et al. Get a grip on immune cells by inhibiting JAKs. Oncoimmunology. 2015;5(2):e1071009doi: 10.1080/2162402X.2015.1071009.
Schönberg, K., Rudolph, J., Yajnanarayana, S. P., & Wolf, D. (2016). Get a grip on immune cells by inhibiting JAKs. Oncoimmunology, 5(2), e1071009. https://doi.org/10.1080/2162402X.2015.1071009
Schönberg, Kathrin, et al. "Get a grip on immune cells by inhibiting JAKs." Oncoimmunology vol. 5,2 (2016): e1071009. doi: https://doi.org/10.1080/2162402X.2015.1071009
Schönberg K, Rudolph J, Yajnanarayana SP, Wolf D. Get a grip on immune cells by inhibiting JAKs. Oncoimmunology. 2015 Aug 12;5(2):e1071009. doi: 10.1080/2162402X.2015.1071009. eCollection 2016 Feb. PMID: 27057437; PMCID: PMC4801466.
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Oncoimmunology. 2015 Aug 12;5(2):e1071009. doi: 10.1080/2162402X.2015.1071009. eCollection 2016 Feb.

Get a grip on immune cells by inhibiting JAKs.

Oncoimmunology

Kathrin Schönberg, Janna Rudolph, Sowmya Parampalli Yajnanarayana, Dominik Wolf

Affiliations

  1. Department of Internal Medicine III, Oncology, Hematology and Rheumatology, University Clinic Bonn (UKB) , Bonn, Germany.
  2. Department of Internal Medicine III, Oncology, Hematology and Rheumatology, University Clinic Bonn (UKB), Bonn, Germany; Laboratory for Tumorimmunology, Department of Medicine V, Medical University Innsbruck, Innsbruck, Austria.

PMID: 27057437 PMCID: PMC4801466 DOI: 10.1080/2162402X.2015.1071009

Abstract

JAK inhibitors are approved for myelofibrosis (MF) and polycythemia vera (PV), as they reverse inflammation-associated splenomegaly and symptoms. Notably, JAK inhibitors only marginally affect disease burden. The anti-inflammatory effects of JAK inhibitors affects DC, T and NK cells explaining their therapeutic potential for limitation of cancer-associated inflammation, Graft-

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