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Nagayama Y, Shimamura M, Mitsutake N. Cancer Stem Cells in the Thyroid. Front Endocrinol (Lausanne). 2016;7:20doi: 10.3389/fendo.2016.00020.
Nagayama, Y., Shimamura, M., & Mitsutake, N. (2016). Cancer Stem Cells in the Thyroid. Frontiers in endocrinology, 720. https://doi.org/10.3389/fendo.2016.00020
Nagayama, Yuji, et al. "Cancer Stem Cells in the Thyroid." Frontiers in endocrinology vol. 7 (2016): 20. doi: https://doi.org/10.3389/fendo.2016.00020
Nagayama Y, Shimamura M, Mitsutake N. Cancer Stem Cells in the Thyroid. Front Endocrinol (Lausanne). 2016 Feb 29;7:20. doi: 10.3389/fendo.2016.00020. eCollection 2016. PMID: 26973599; PMCID: PMC4770029.
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Front Endocrinol (Lausanne). 2016 Feb 29;7:20. doi: 10.3389/fendo.2016.00020. eCollection 2016.

Cancer Stem Cells in the Thyroid.

Frontiers in endocrinology

Yuji Nagayama, Mika Shimamura, Norisato Mitsutake

Affiliations

  1. Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University , Nagasaki , Japan.
  2. Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University , Nagasaki , Japan.

PMID: 26973599 PMCID: PMC4770029 DOI: 10.3389/fendo.2016.00020

Abstract

The cancer stem cell (CSC) model posits that CSCs are a small, biologically distinct subpopulation of cancer cells in each tumor that have self-renewal and multi-lineage potential, and are critical for cancer initiation, metastasis, recurrence, and therapy-resistance. Numerous studies have linked CSCs to thyroid biology, but the candidate markers and signal transduction pathways that drive thyroid CSC growth are controversial, the origin(s) of thyroid CSCs remain elusive, and it is unclear whether thyroid CSC biology is consistent with the original hierarchical CSC model or the more recent dynamic CSC model. Here, we critically review the thyroid CSC literature with an emphasis on research that confirmed the presence of thyroid CSCs by in vitro sphere formation or in vivo tumor formation assays with dispersed cells from thyroid cancer tissues or bona fide thyroid cancer cell lines. Future perspectives of thyroid CSC research are also discussed.

Keywords: aldehyde dehydrogenase; cancer stem cells; epithelial–mesenchymal transition; thyroid cancer; thyrosphere

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