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Beck M, Barelkowski T, Kaul D, et al. Role of Dose Intensification for Salvage Radiation Therapy after Radical Prostatectomy. Front Oncol. 2016;6:48doi: 10.3389/fonc.2016.00048.
Beck, M., Barelkowski, T., Kaul, D., Wecker, S., Thieme, A. H., Zwahlen, D. R., Wust, P., Aebersold, D. M., Budach, V., & Ghadjar, P. (2016). Role of Dose Intensification for Salvage Radiation Therapy after Radical Prostatectomy. Frontiers in oncology, 648. https://doi.org/10.3389/fonc.2016.00048
Beck, Marcus, et al. "Role of Dose Intensification for Salvage Radiation Therapy after Radical Prostatectomy." Frontiers in oncology vol. 6 (2016): 48. doi: https://doi.org/10.3389/fonc.2016.00048
Beck M, Barelkowski T, Kaul D, Wecker S, Thieme AH, Zwahlen DR, Wust P, Aebersold DM, Budach V, Ghadjar P. Role of Dose Intensification for Salvage Radiation Therapy after Radical Prostatectomy. Front Oncol. 2016 Mar 01;6:48. doi: 10.3389/fonc.2016.00048. eCollection 2016. PMID: 26973815; PMCID: PMC4771737.
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Front Oncol. 2016 Mar 01;6:48. doi: 10.3389/fonc.2016.00048. eCollection 2016.

Role of Dose Intensification for Salvage Radiation Therapy after Radical Prostatectomy.

Frontiers in oncology

Marcus Beck, Tomasz Barelkowski, David Kaul, Sascha Wecker, Alexander H Thieme, Daniel R Zwahlen, Peter Wust, Daniel M Aebersold, Volker Budach, Pirus Ghadjar

Affiliations

  1. Department of Radiation Oncology, Charité Universitätsmedizin Berlin , Berlin , Germany.
  2. Kantonsspital Graubünden , Chur , Switzerland.
  3. Bern University Hospital, University of Bern , Bern , Switzerland.

PMID: 26973815 PMCID: PMC4771737 DOI: 10.3389/fonc.2016.00048

Abstract

For primary radiation therapy (RT) of prostate cancer, dose intensification is established as standard of care. Less is known on the role of dose intensification in the postprostatectomy setting for salvage RT. Thus, we aimed to identify and summarize the existing literature. In retrospective analyses, dose-intensified salvage RT showed a superior biochemical control compared to standard dose salvage radiation with favorable acute and late gastrointestinal and genitourinary toxicity rates, especially when modern radiation techniques such as intensity modulated RT were applied. We identified one randomized phase III trial addressing the potential benefits of dose-intensified salvage RT (SAKK 09/10). Recently, acute gastrointestinal and genitourinary toxicities and early quality of life data of this trial were reported, and no significant difference in acute toxicities between both treatment arms were found; however, a significant worsening of genitourinary quality of life was noted in the dose-intensified treatment arm. Whereas dose-intensified salvage RT appears to be feasible and well tolerated, the improved biochemical control rates using dose intensified RT as suggested by retrospective analyses have yet to be validated by prospective trials.

Keywords: dose; prostate cancer; prostatectomy; radiation therapy; salvage

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