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Page K, Mirzazadeh A, Rice TM, et al. Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative. Open Forum Infect Dis. 2016;3(1):ofw024doi: 10.1093/ofid/ofw024.
Page, K., Mirzazadeh, A., Rice, T. M., Grebely, J., Kim, A. Y., Cox, A. L., Morris, M. D., Hellard, M., Bruneau, J., Shoukry, N. H., Dore, G. J., Maher, L., Lloyd, A. R., Lauer, G., Prins, M., & McGovern, B. H. (2016). Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative. Open forum infectious diseases, 3(1), ofw024. https://doi.org/10.1093/ofid/ofw024
Page, Kimberly, et al. "Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative." Open forum infectious diseases vol. 3,1 (2016): ofw024. doi: https://doi.org/10.1093/ofid/ofw024
Page K, Mirzazadeh A, Rice TM, Grebely J, Kim AY, Cox AL, Morris MD, Hellard M, Bruneau J, Shoukry NH, Dore GJ, Maher L, Lloyd AR, Lauer G, Prins M, McGovern BH. Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative. Open Forum Infect Dis. 2016 Feb 08;3(1):ofw024. doi: 10.1093/ofid/ofw024. eCollection 2016 Jan. PMID: 26973850; PMCID: PMC4785397.
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Open Forum Infect Dis. 2016 Feb 08;3(1):ofw024. doi: 10.1093/ofid/ofw024. eCollection 2016 Jan.

Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.

Open forum infectious diseases

Kimberly Page, Ali Mirzazadeh, Thomas M Rice, Jason Grebely, Arthur Y Kim, Andrea L Cox, Meghan D Morris, Margaret Hellard, Julie Bruneau, Naglaa H Shoukry, Gregory J Dore, Lisa Maher, Andrew R Lloyd, Georg Lauer, Maria Prins, Barbara H McGovern

Affiliations

  1. Division of Epidemiology, Biostatistics and Preventive Medicine , University of New Mexico Health Sciences Center , Albuquerque, New Mexico.
  2. Department of Epidemiology and Biostatistics , University of California San Francisco.
  3. The Kirby Institute for Infection and Immunity in Society.
  4. Harvard Medical School , Boston, Massachusetts.
  5. Department of Medicine , Johns Hopkins Medical Institutions , Baltimore, Maryland.
  6. Burnet Institute , Melbourne, Victoria , Australia.
  7. Centre Hospitalier de l'Université de Montréal , Quebec , Canada.
  8. School of Medical Sciences , University of New South Wales , Sydney , Australia.
  9. GGD Public Health Service of Amsterdam , The Netherlands.
  10. Seres Therapeutics , Cambridge, Massachusetts.

PMID: 26973850 PMCID: PMC4785397 DOI: 10.1093/ofid/ofw024

Abstract

Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease.

Keywords: IFNL4; acute infection; alanine aminotransferase; hepatitis C virus; jaundice

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