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Shinkai T, Masumoto K, Ono K, et al. A case of unusual histology of infantile lipoblastoma confirmed by PLAG1 rearrangement. Surg Case Rep. 2015;1(1):42doi: 10.1186/s40792-015-0042-4.
Shinkai, T., Masumoto, K., Ono, K., Yano, E., Kobayashi, C., Fukushima, T., Sumazaki, R., Satomi, K., & Noguchi, M. (2015). A case of unusual histology of infantile lipoblastoma confirmed by PLAG1 rearrangement. Surgical case reports, 1(1), 42. https://doi.org/10.1186/s40792-015-0042-4
Shinkai, Toko, et al. "A case of unusual histology of infantile lipoblastoma confirmed by PLAG1 rearrangement." Surgical case reports vol. 1,1 (2015): 42. doi: https://doi.org/10.1186/s40792-015-0042-4
Shinkai T, Masumoto K, Ono K, Yano E, Kobayashi C, Fukushima T, Sumazaki R, Satomi K, Noguchi M. A case of unusual histology of infantile lipoblastoma confirmed by PLAG1 rearrangement. Surg Case Rep. 2015 Dec;1(1):42. doi: 10.1186/s40792-015-0042-4. Epub 2015 May 16. PMID: 26943407; PMCID: PMC4747941.
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Surg Case Rep. 2015 Dec;1(1):42. doi: 10.1186/s40792-015-0042-4. Epub 2015 May 16.

A case of unusual histology of infantile lipoblastoma confirmed by PLAG1 rearrangement.

Surgical case reports

Toko Shinkai, Kouji Masumoto, Kentaro Ono, Eri Yano, Chie Kobayashi, Takashi Fukushima, Ryo Sumazaki, Kaishi Satomi, Masayuki Noguchi

Affiliations

  1. Department of Pediatric Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. [email protected].
  2. Department of Pediatric Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. [email protected].
  3. Department of Pediatric Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. [email protected].
  4. Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. [email protected].
  5. Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. [email protected].
  6. Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. [email protected].
  7. Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. [email protected].
  8. Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. [email protected].
  9. Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. [email protected].

PMID: 26943407 PMCID: PMC4747941 DOI: 10.1186/s40792-015-0042-4

Abstract

Lipoblastoma, a relatively rare benign adipose neoplasm, predominantly affects children younger than 3 years of age. We herein report the case of a 7-month-old girl with an unusual myxomatous histology of lipoblastoma. A rapidly growing mass was detected in the subcutaneous area of the left buttock. Histologically, the tumor consisted of abundant myxoid stroma exhibiting cellular atypia and a high mitotic activity. Although the histological findings were unusual, the tumor was diagnosed as a lipoblastoma according to both PLAG1 immunohistochemistry and the presence of PLAG1 rearrangement on fluorescence in situ hybridization.

Keywords: Fluorescence in situ hybridization (FISH); Immunohistochemistry (IHC); Lipoblastoma; PLAG1

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