Display options
Cite
Snyder DT, Pulliam CJ, Wiley JS, et al. Experimental Characterization of Secular Frequency Scanning in Ion Trap Mass Spectrometers. J Am Soc Mass Spectrom. 2016;27(7):1243-55doi: 10.1007/s13361-016-1377-1.
Snyder, D. T., Pulliam, C. J., Wiley, J. S., Duncan, J., & Cooks, R. G. (2016). Experimental Characterization of Secular Frequency Scanning in Ion Trap Mass Spectrometers. Journal of the American Society for Mass Spectrometry, 27(7), 1243-55. https://doi.org/10.1007/s13361-016-1377-1
Snyder, Dalton T, et al. "Experimental Characterization of Secular Frequency Scanning in Ion Trap Mass Spectrometers." Journal of the American Society for Mass Spectrometry vol. 27,7 (2016): 1243-55. doi: https://doi.org/10.1007/s13361-016-1377-1
Snyder DT, Pulliam CJ, Wiley JS, Duncan J, Cooks RG. Experimental Characterization of Secular Frequency Scanning in Ion Trap Mass Spectrometers. J Am Soc Mass Spectrom. 2016 Jul;27(7):1243-55. doi: 10.1007/s13361-016-1377-1. Epub 2016 Mar 31. PMID: 27032650.
Copy Download .nbib Format: NLM
Share it on

J Am Soc Mass Spectrom. 2016 Jul;27(7):1243-55. doi: 10.1007/s13361-016-1377-1. Epub 2016 Mar 31.

Experimental Characterization of Secular Frequency Scanning in Ion Trap Mass Spectrometers.

Journal of the American Society for Mass Spectrometry

Dalton T Snyder, Christopher J Pulliam, Joshua S Wiley, Jason Duncan, R Graham Cooks

Affiliations

  1. Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, IN, 47907, USA.
  2. Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, IN, 47907, USA. [email protected].

PMID: 27032650 DOI: 10.1007/s13361-016-1377-1

Abstract

Secular frequency scanning is implemented and characterized using both a benchtop linear ion trap and a miniature rectilinear ion trap mass spectrometer. Separation of tetraalkylammonium ions and those from a mass calibration mixture and from a pesticide mixture is demonstrated with peak widths approaching unit resolution for optimized conditions using the benchtop ion trap. The effects on the spectra of ion trap operating parameters, including waveform amplitude, scan direction, scan rate, and pressure are explored, and peaks at black holes corresponding to nonlinear (higher-order field) resonance points are investigated. Reverse frequency sweeps (increasing mass) on the Mini 12 are shown to result in significantly higher ion ejection efficiency and superior resolution than forward frequency sweeps that decrement mass. This result is accounted for by the asymmetry in ion energy absorption profiles as a function of AC frequency and the shift in ion secular frequency at higher amplitudes in the trap due to higher order fields. We also found that use of higher AC amplitudes in forward frequency sweeps biases ions toward ejection at points of higher order parametric resonance, despite using only dipolar excitation. Higher AC amplitudes also increase peak width and decrease sensitivity in both forward and reverse frequency sweeps. Higher sensitivity and resolution were obtained at higher trap pressures in the secular frequency scan, in contrast to conventional resonance ejection scans, which showed the opposite trend in resolution on the Mini 12. Mass range is shown to be naturally extended in secular frequency scanning when ejecting ions by sweeping the AC waveform through low frequencies, a method which is similar, but arguably superior, to the more usual method of mass range extension using low q resonance ejection. Graphical Abstract ᅟ.

Keywords: Collision-induced dissociation; Higher order fields; Ion ejection; Ion motion; Miniature mass spectrometer; Simulations; Tandem mass spectrometry

References

  1. J Am Soc Mass Spectrom. 2002 May;13(5):577-86 - PubMed
  2. J Am Soc Mass Spectrom. 2000 Nov;11(11):1016-22 - PubMed
  3. Rapid Commun Mass Spectrom. 2016 May 30;30(10 ):1190-1196 - PubMed
  4. J Mass Spectrom. 2004 May;39(5):471-84 - PubMed
  5. Mass Spectrom Rev. 2009 Nov-Dec;28(6):961-89 - PubMed
  6. Anal Chem. 2004 Aug 15;76(16):4595-605 - PubMed
  7. Anal Chem. 2013 Nov 19;85(22):10935-40 - PubMed
  8. J Am Soc Mass Spectrom. 2006 Jul;17(7):916-22 - PubMed
  9. Phys Rev Lett. 2005 Feb 11;94(5):053001 - PubMed
  10. J Am Soc Mass Spectrom. 2002 Jun;13(6):659-69 - PubMed
  11. J Am Soc Mass Spectrom. 2011 Feb;22(2):369-78 - PubMed
  12. Annu Rev Anal Chem (Palo Alto Calif). 2009;2:187-214 - PubMed
  13. Anal Chem. 2008 Jun 1;80(11):4026-32 - PubMed
  14. Mass Spectrom Rev. 2005 Jan-Feb;24(1):1-29 - PubMed
  15. J Am Soc Mass Spectrom. 2006 Sep;17(9):1216-28 - PubMed
  16. J Mass Spectrom. 2000 Jun;35(6):659-71 - PubMed
  17. Rapid Commun Mass Spectrom. 2002;16(8):755-60 - PubMed
  18. J Am Soc Mass Spectrom. 1991 May;2(3):198-204 - PubMed
  19. J Am Soc Mass Spectrom. 2009 Nov;20(11):2144-53 - PubMed
  20. Rapid Commun Mass Spectrom. 2016 Apr 15;30(7):800-4 - PubMed
  21. Anal Chem. 2007 Apr 1;79(7):2927-32 - PubMed
  22. Anal Chem. 2016 Jan 5;88(1):2-29 - PubMed
  23. Anal Chem. 2014 Mar 18;86(6):2909-16 - PubMed
  24. Anal Chem. 2011 Jul 15;83(14):5578-84 - PubMed

Publication Types