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Oda E, Hashimoto D, Shiomi Y, et al. A case of occult intrahepatic cholangiocarcinoma diagnosed by autopsy. Surg Case Rep. 2015;1(1):101doi: 10.1186/s40792-015-0106-5.
Oda, E., Hashimoto, D., Shiomi, Y., Ohnishi, K., Hayashi, H., Chikamoto, A., Takeya, M., & Baba, H. (2015). A case of occult intrahepatic cholangiocarcinoma diagnosed by autopsy. Surgical case reports, 1(1), 101. https://doi.org/10.1186/s40792-015-0106-5
Oda, Eri, et al. "A case of occult intrahepatic cholangiocarcinoma diagnosed by autopsy." Surgical case reports vol. 1,1 (2015): 101. doi: https://doi.org/10.1186/s40792-015-0106-5
Oda E, Hashimoto D, Shiomi Y, Ohnishi K, Hayashi H, Chikamoto A, Takeya M, Baba H. A case of occult intrahepatic cholangiocarcinoma diagnosed by autopsy. Surg Case Rep. 2015 Dec;1(1):101. doi: 10.1186/s40792-015-0106-5. Epub 2015 Oct 14. PMID: 26943425; PMCID: PMC4605921.
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Surg Case Rep. 2015 Dec;1(1):101. doi: 10.1186/s40792-015-0106-5. Epub 2015 Oct 14.

A case of occult intrahepatic cholangiocarcinoma diagnosed by autopsy.

Surgical case reports

Eri Oda, Daisuke Hashimoto, Yuko Shiomi, Koji Ohnishi, Hiromitsu Hayashi, Akira Chikamoto, Motohiro Takeya, Hideo Baba

Affiliations

  1. Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan. [email protected].
  2. Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan. [email protected].
  3. Division of Surgical Pathology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan. [email protected].
  4. Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan. [email protected].
  5. Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan. [email protected].
  6. Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan. [email protected].
  7. Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan. [email protected].
  8. Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan. [email protected].
  9. Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan. [email protected].

PMID: 26943425 PMCID: PMC4605921 DOI: 10.1186/s40792-015-0106-5

Abstract

Cancer of unknown primary is associated with unknown biology and dismal prognosis. The most common primary sites of cancer of unknown primary were usually the lungs in autopsy studies, and intrahepatic cholangiocarcinoma is rare. We describe the case of a 57-year-old male patient with systemic lymph node metastasis. Imaging examination failed to reveal primary cancer; however, immunostaining of cytokeratins 7, 19, and 20 of a metastatic axillary lymph node suggested a pancreaticobiliary cancer as a primary lesion. He died of liver abscess and sepsis, and then, autopsy indicated occult intrahepatic cholangiocarcinoma. We discuss the clinical course of this rare cholangiocarcinoma including the diagnostic procedure and also present a review of the English literature regarding patients with cancer of unknown primary.

Keywords: Autopsy; Cancer of unknown primary; Intrahepatic cholangiocarcinoma

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