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Takahashi K, Ito H, Katsube T, et al. Immunoglobulin G4-related sclerosing cholecystitis presenting as gallbladder cancer: a case report. Surg Case Rep. 2015;1(1):120doi: 10.1186/s40792-015-0123-4.
Takahashi, K., Ito, H., Katsube, T., Tsuboi, A., Hashimoto, M., Ota, E., Mita, K., Asakawa, H., Hayashi, T., Fujino, K., & Okamoto, S. (2015). Immunoglobulin G4-related sclerosing cholecystitis presenting as gallbladder cancer: a case report. Surgical case reports, 1(1), 120. https://doi.org/10.1186/s40792-015-0123-4
Takahashi, Kodai, et al. "Immunoglobulin G4-related sclerosing cholecystitis presenting as gallbladder cancer: a case report." Surgical case reports vol. 1,1 (2015): 120. doi: https://doi.org/10.1186/s40792-015-0123-4
Takahashi K, Ito H, Katsube T, Tsuboi A, Hashimoto M, Ota E, Mita K, Asakawa H, Hayashi T, Fujino K, Okamoto S. Immunoglobulin G4-related sclerosing cholecystitis presenting as gallbladder cancer: a case report. Surg Case Rep. 2015 Dec;1(1):120. doi: 10.1186/s40792-015-0123-4. Epub 2015 Dec 03. PMID: 26943444; PMCID: PMC4668245.
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Surg Case Rep. 2015 Dec;1(1):120. doi: 10.1186/s40792-015-0123-4. Epub 2015 Dec 03.

Immunoglobulin G4-related sclerosing cholecystitis presenting as gallbladder cancer: a case report.

Surgical case reports

Kodai Takahashi, Hideto Ito, Toshio Katsube, Ayaka Tsuboi, Masatoshi Hashimoto, Emi Ota, Kazuhito Mita, Hideki Asakawa, Takashi Hayashi, Keiichi Fujino, Sigeru Okamoto

Affiliations

  1. Department of Surgery, New Tokyo Hospital, 1271 Wanagaya, Matsudo City, Chiba, Japan. [email protected].
  2. Department of Surgery, New Tokyo Hospital, 1271 Wanagaya, Matsudo City, Chiba, Japan. [email protected].
  3. Department of Surgery, New Tokyo Hospital, 1271 Wanagaya, Matsudo City, Chiba, Japan. [email protected].
  4. Department of Surgery, New Tokyo Hospital, 1271 Wanagaya, Matsudo City, Chiba, Japan. [email protected].
  5. Department of Surgery, New Tokyo Hospital, 1271 Wanagaya, Matsudo City, Chiba, Japan. [email protected].
  6. Department of Surgery, New Tokyo Hospital, 1271 Wanagaya, Matsudo City, Chiba, Japan. [email protected].
  7. Department of Surgery, New Tokyo Hospital, 1271 Wanagaya, Matsudo City, Chiba, Japan. [email protected].
  8. Department of Surgery, New Tokyo Hospital, 1271 Wanagaya, Matsudo City, Chiba, Japan. [email protected].
  9. Department of Surgery, New Tokyo Hospital, 1271 Wanagaya, Matsudo City, Chiba, Japan. [email protected].
  10. Department of Surgery, New Tokyo Hospital, 1271 Wanagaya, Matsudo City, Chiba, Japan. [email protected].
  11. Department of Pathology, New Tokyo Hospital, 1271 Wanagaya, Matsudo City, Chiba, Japan. [email protected].

PMID: 26943444 PMCID: PMC4668245 DOI: 10.1186/s40792-015-0123-4

Abstract

Immunoglobulin G4 (IgG4)-related sclerosing disease is a systemic inflammatory syndrome, and an understanding of its characteristics is currently evolving. IgG4-related cholecystitis is a manifestation of IgG4-related sclerosing disease in the gallbladder. This case report describes the clinical, radiographic, and histopathological findings in a young male patient who presented with a synchronous mass in the gallbladder. Serum levels of IgG4 and the IgG4/IgG ratio were normal, and there was no associated autoimmune pancreatitis. Therefore, establishing a preoperative diagnosis of IgG4-related cholecystitis was very difficult, and a differential diagnosis of gallbladder cancer infiltrating the liver was suggested. Postoperative histopathological examination established a diagnosis of IgG4-related cholecystitis definitively. A preoperative diagnosis of IgG4-related cholecystitis, although possible, would have been highly challenging in this case. It is difficult to establish whether surgical intervention is necessary in IgG4-related cholecystitis. Because malignant tumors are frequently suspected with this clinical presentation, surgical intervention should be undertaken only after due deliberation.

Keywords: Gallbladder cancer; IgG4-related cholecystitis; IgG4-related sclerosing disease

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