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Adachi Y, Kikumori T, Miyajima N, et al. Postoperative elevation of CA15-3 due to pernicious anemia in a patient without evidence of breast cancer recurrence. Surg Case Rep. 2015;1(1):126doi: 10.1186/s40792-015-0128-z.
Adachi, Y., Kikumori, T., Miyajima, N., Inaishi, T., Onishi, E., Shibata, M., Nakanishi, K., Takeuchi, D., Hayashi, H., & Kodera, Y. (2015). Postoperative elevation of CA15-3 due to pernicious anemia in a patient without evidence of breast cancer recurrence. Surgical case reports, 1(1), 126. https://doi.org/10.1186/s40792-015-0128-z
Adachi, Yayoi, et al. "Postoperative elevation of CA15-3 due to pernicious anemia in a patient without evidence of breast cancer recurrence." Surgical case reports vol. 1,1 (2015): 126. doi: https://doi.org/10.1186/s40792-015-0128-z
Adachi Y, Kikumori T, Miyajima N, Inaishi T, Onishi E, Shibata M, Nakanishi K, Takeuchi D, Hayashi H, Kodera Y. Postoperative elevation of CA15-3 due to pernicious anemia in a patient without evidence of breast cancer recurrence. Surg Case Rep. 2015 Dec;1(1):126. doi: 10.1186/s40792-015-0128-z. Epub 2015 Dec 30. PMID: 26943450; PMCID: PMC4696936.
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Surg Case Rep. 2015 Dec;1(1):126. doi: 10.1186/s40792-015-0128-z. Epub 2015 Dec 30.

Postoperative elevation of CA15-3 due to pernicious anemia in a patient without evidence of breast cancer recurrence.

Surgical case reports

Yayoi Adachi, Toyone Kikumori, Noriyuki Miyajima, Takahiro Inaishi, Eiji Onishi, Masahiro Shibata, Kenichi Nakanishi, Dai Takeuchi, Hironori Hayashi, Yasuhiro Kodera

Affiliations

  1. Department of Transplantation and Endocrine Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8560, Japan. [email protected].
  2. Department of Transplantation and Endocrine Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8560, Japan. [email protected].
  3. Department of Transplantation and Endocrine Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8560, Japan. [email protected].
  4. Department of Transplantation and Endocrine Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8560, Japan. [email protected].
  5. Department of Transplantation and Endocrine Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8560, Japan. [email protected].
  6. Department of Transplantation and Endocrine Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8560, Japan. [email protected].
  7. Department of Transplantation and Endocrine Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8560, Japan. [email protected].
  8. Department of Transplantation and Endocrine Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8560, Japan. [email protected].
  9. Department of Transplantation and Endocrine Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8560, Japan. [email protected].
  10. Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa, Nagoya, Aichi, 466-8560, Japan. [email protected].

PMID: 26943450 PMCID: PMC4696936 DOI: 10.1186/s40792-015-0128-z

Abstract

Cancer antigen 15-3 (CA15-3) is considered as a marker for breast cancer recurrence. However, we encountered a case where the patient showed postoperative elevation of the CA15-3 level due to pernicious anemia without evidence of breast cancer recurrence. The patient was a 60-year-old postmenopausal woman. She had undergone partial mastectomy and sentinel lymph node biopsy (SLNB) for her T1 left breast cancer. SLNB had indicated no lymph node metastases. The tumor was positive for hormone receptors and negative for human epidermal growth factor receptor 2. Therefore, an aromatase inhibitor and external beam irradiation had been administered as adjuvant therapy. However, the CA15-3 level was found to be elevated at 6 months postoperatively. Although imaging studies did not indicate breast cancer recurrence, CA15-3 levels continued to increase. Based on the findings of blood tests and gastroendoscopy, a diagnosis of pernicious anemia due to vitamin B12 deficiency was finally confirmed at 2 years and 6 months postoperatively. The CA15-3 level returned to normal after vitamin B12 administration. The possibility of pernicious anemia should be considered in cases of postoperative elevated CA15-3 levels with no evidence of recurrence in patients with early breast cancer.

Keywords: Breast cancer; CA15-3; Pernicious anemia

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