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Tan X, Wang G, Zhu Z, et al. Hydrogenation of Aldehydes Catalyzed by an Available Ruthenium Complex. Org Lett. 2016;18(7):1518-21doi: 10.1021/acs.orglett.6b00060.
Tan, X., Wang, G., Zhu, Z., Ren, C., Zhou, J., Lv, H., Zhang, X., Chung, L. W., Zhang, L., & Zhang, X. (2016). Hydrogenation of Aldehydes Catalyzed by an Available Ruthenium Complex. Organic letters, 18(7), 1518-21. https://doi.org/10.1021/acs.orglett.6b00060
Tan, Xuefeng, et al. "Hydrogenation of Aldehydes Catalyzed by an Available Ruthenium Complex." Organic letters vol. 18,7 (2016): 1518-21. doi: https://doi.org/10.1021/acs.orglett.6b00060
Tan X, Wang G, Zhu Z, Ren C, Zhou J, Lv H, Zhang X, Chung LW, Zhang L, Zhang X. Hydrogenation of Aldehydes Catalyzed by an Available Ruthenium Complex. Org Lett. 2016 Apr 01;18(7):1518-21. doi: 10.1021/acs.orglett.6b00060. Epub 2016 Mar 14. PMID: 26974348.
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Org Lett. 2016 Apr 01;18(7):1518-21. doi: 10.1021/acs.orglett.6b00060. Epub 2016 Mar 14.

Hydrogenation of Aldehydes Catalyzed by an Available Ruthenium Complex.

Organic letters

Xuefeng Tan, Guozhen Wang, Ziyue Zhu, Conghui Ren, Jinping Zhou, Hui Lv, Xiaoyong Zhang, Lung Wa Chung, Lina Zhang, Xumu Zhang

Affiliations

  1. College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, People's Republic of China.
  2. Department of Chemistry, South University of Science and Technology of China , Shenzhen 518055, China.

PMID: 26974348 DOI: 10.1021/acs.orglett.6b00060

Abstract

A readily available ruthenium(II) catalyst was developed for the catalytic hydrogenation of aldehydes with a TON (turnover number) up to 340000. It can be performed without base and solvent, showing highly industrial potential. High chemoselectivity can be achieved in the presence of alkenyl and ketone groups. Further application of this protocol in glucose reduction showed good efficiency. Theoretical studies revealed that the rate-determining step is the hydrogenation step, not the carboxylate-assisted H2 activation step.

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