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Clujul Med. 2016;89(1):24-31. doi: 10.15386/cjmed-554. Epub 2016 Jan 15.

Hyaluronic acid as a biomarker of fibrosis in chronic liver diseases of different etiologies.

Clujul medical (1957)

Olga Hilda Orasan, George Ciulei, Angela Cozma, Madalina Sava, Dan Lucian Dumitrascu

Affiliations

  1. 4th Medical Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  2. 2nd Medical Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

PMID: 27004022 PMCID: PMC4777465 DOI: 10.15386/cjmed-554

Abstract

Chronic liver diseases represent a significant public health problem worldwide. The degree of liver fibrosis secondary to these diseases is important, because it is the main predictor of their evolution and prognosis. Hyaluronic acid is studied as a non-invasive marker of liver fibrosis in chronic liver diseases, in an attempt to avoid the complications of liver puncture biopsy, considered the gold standard in the evaluation of fibrosis. We review the advantages and limitations of hyaluronc acid, a biomarker, used to manage patients with chronic viral hepatitis B or C infection, non-alcoholic fatty liver disease, HIV-HCV coinfection, alcoholic liver disease, primary biliary cirrhosis, biliary atresia, hereditary hemochromatosis and cystic fibrosis.

Keywords: chronic liver diseases; hyaluronic acid; liver fibrosis

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