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Sobczak S, Honig A, Riedel WJ. Acute tryptophan depletion in bipolar disorders; literature review and directives for further research. Acta Neuropsychiatr. 2000;12(3):69-72doi: 10.1017/S0924270800035432.
Sobczak, S., Honig, A., & Riedel, W. J. (2000). Acute tryptophan depletion in bipolar disorders; literature review and directives for further research. Acta neuropsychiatrica, 12(3), 69-72. https://doi.org/10.1017/S0924270800035432
Sobczak, S, et al. "Acute tryptophan depletion in bipolar disorders; literature review and directives for further research." Acta neuropsychiatrica vol. 12,3 (2000): 69-72. doi: https://doi.org/10.1017/S0924270800035432
Sobczak S, Honig A, Riedel WJ. Acute tryptophan depletion in bipolar disorders; literature review and directives for further research. Acta Neuropsychiatr. 2000 Sep;12(3):69-72. doi: 10.1017/S0924270800035432. PMID: 26975255.
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Acta Neuropsychiatr. 2000 Sep;12(3):69-72. doi: 10.1017/S0924270800035432.

Acute tryptophan depletion in bipolar disorders; literature review and directives for further research.

Acta neuropsychiatrica

S Sobczak, A Honig, W J Riedel

Affiliations

  1. Institute Brain and Behaviour,Dept. of Psychiatry,Maastricht,The Netherlands.

PMID: 26975255 DOI: 10.1017/S0924270800035432

Abstract

Serotonin (5-HT) has been implicated in the pathophysiology of bipolar disorders. Acute tryptophan depletion (ATD), which decreases serotonergic turnover, is an established paradigm to study serotonergic vulnerability in affective disorders. Literature on the application of ATD as a research tool in bipolar patients is limited to three studies, which revealed inconsistent results on mood modification. These inconsistencies may be attributed to differences in methodological procedures and / or characteristics of included patients. Patient selection, methodological aspects and procedures of these studies are critically considered and recommendations given. A research protocol to test the 5-HT vulnerability in bipolar disorder is proposed.

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