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Nemes A, Piros GÁ, Lengyel C, et al. Complex evaluation of left atrial dysfunction in patients with type 1 diabetes mellitus by three-dimensional speckle tracking echocardiography: results from the MAGYAR-Path Study. Anatol J Cardiol. 2015;16(8):587-593doi: 10.5152/AnatolJCardiol.2015.6225.
Nemes, A., Piros, G. �. �., Lengyel, C., Domsik, P., Kalapos, A., Várkonyi, T. T., Orosz, A., & Forster, T. (2016). Complex evaluation of left atrial dysfunction in patients with type 1 diabetes mellitus by three-dimensional speckle tracking echocardiography: results from the MAGYAR-Path Study. Anatolian journal of cardiology, 16(8), 587-593. https://doi.org/10.5152/AnatolJCardiol.2015.6225
Nemes, Attila, et al. "Complex evaluation of left atrial dysfunction in patients with type 1 diabetes mellitus by three-dimensional speckle tracking echocardiography: results from the MAGYAR-Path Study." Anatolian journal of cardiology vol. 16,8 (2016): 587-593. doi: https://doi.org/10.5152/AnatolJCardiol.2015.6225
Nemes A, Piros GÁ, Lengyel C, Domsik P, Kalapos A, Várkonyi TT, Orosz A, Forster T. Complex evaluation of left atrial dysfunction in patients with type 1 diabetes mellitus by three-dimensional speckle tracking echocardiography: results from the MAGYAR-Path Study. Anatol J Cardiol. 2016 Aug;16(8):587-593. doi: 10.5152/AnatolJCardiol.2015.6225. Epub 2015 Nov 25. PMID: 27004713; PMCID: PMC5368514.
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Anatol J Cardiol. 2016 Aug;16(8):587-593. doi: 10.5152/AnatolJCardiol.2015.6225. Epub 2015 Nov 25.

Complex evaluation of left atrial dysfunction in patients with type 1 diabetes mellitus by three-dimensional speckle tracking echocardiography: results from the MAGYAR-Path Study.

Anatolian journal of cardiology

Attila Nemes, Györgyike Ágnes Piros, Csaba Lengyel, Péter Domsik, Anita Kalapos, Tamás T Várkonyi, Andrea Orosz, Tamás Forster

Affiliations

  1. 2nd Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged-Hungary. [email protected].
  2. 2nd Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged-Hungary.
  3. 1st Department of Medicine, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged-Hungary.
  4. Department of Pharmacology and Pharmacotherapy, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged-Hungary.

PMID: 27004713 PMCID: PMC5368514 DOI: 10.5152/AnatolJCardiol.2015.6225

Abstract

OBJECTIVE: Changes in left atrial (LA) function can be observed in type 1 diabetes mellitus (T1DM). Three-dimensional (3-D) speckle tracking echocardiography (STE) seems to be a promising tool for volumetric and functional evaluation of LA. The objective of the present study was to compare 3DSTE-derived LA volumetric and strain parameters between T1DM patients and matched healthy controls.

METHODS: This prospective study consists of 17 subcutaneous insulin pump-treated non-obese patients with T1DM (mean age: 33.5±8.2 years, 8 males). To exclude possible cardiovascular disease, patients with complaints of chest pain, dyspnea, or signs of cerebrovascular disease or peripheral artery disease were not included. Their results were compared with 20 age-matched and gender-matched healthy controls (mean age: 36.9±11.0 years, 9 males). Independent sample Student t-test and Fisher's exact test were used for comparisons. Bland-Altman method was used for evaluating intraobserver and interobserver correlations.

RESULTS: Anemia and impaired renal function were not confirmed in T1DM patients. Calculated LA maximum and minimum volumes and LA volume before atrial contraction were significantly increased in T1DM patients. Total atrial stroke volume was increased (23.6±6.9 mL vs. 19.6±4.6 mL, p=0.04), whereas mean segmental circumferential peak strain was decreased (28.9%±11.4% vs. 37.3%±12.5%, p=0.04). Segmental basal longitudinal and area strains were increased, whereas segmental superior circumferential and area strains and midatrial 3-D strain were decreased in T1DM.

CONCLUSION: Both 3DSTE-derived volumetric and strain analysis confirmed alterations in LA function, suggesting early LA remodeling in patients with T1DM.

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