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Kishibe S, Okubo Y, Morino S, et al. Pediatric hypervirulent Klebsiella pneumoniae septic arthritis. Pediatr Int. 2016;58(5):382-385doi: 10.1111/ped.12806.
Kishibe, S., Okubo, Y., Morino, S., Hirotaki, S., Tame, T., Aoki, K., Ishii, Y., Ota, N., Shimomura, S., Sakakibara, H., Terakawa, T., & Horikoshi, Y. (2016). Pediatric hypervirulent Klebsiella pneumoniae septic arthritis. Pediatrics international : official journal of the Japan Pediatric Society, 58(5), 382-385. https://doi.org/10.1111/ped.12806
Kishibe, Shun, et al. "Pediatric hypervirulent Klebsiella pneumoniae septic arthritis." Pediatrics international : official journal of the Japan Pediatric Society vol. 58,5 (2016): 382-385. doi: https://doi.org/10.1111/ped.12806
Kishibe S, Okubo Y, Morino S, Hirotaki S, Tame T, Aoki K, Ishii Y, Ota N, Shimomura S, Sakakibara H, Terakawa T, Horikoshi Y. Pediatric hypervirulent Klebsiella pneumoniae septic arthritis. Pediatr Int. 2016 May;58(5):382-385. doi: 10.1111/ped.12806. Epub 2016 Mar 23. PMID: 27005513.
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Pediatr Int. 2016 May;58(5):382-385. doi: 10.1111/ped.12806. Epub 2016 Mar 23.

Pediatric hypervirulent Klebsiella pneumoniae septic arthritis.

Pediatrics international : official journal of the Japan Pediatric Society

Shun Kishibe, Yusuke Okubo, Saeko Morino, Shintaro Hirotaki, Tomoyuki Tame, Kotaro Aoki, Yoshikazu Ishii, Norikazu Ota, Satoshi Shimomura, Hiroshi Sakakibara, Toshiro Terakawa, Yuho Horikoshi

Affiliations

  1. Department of General Pediatrics, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
  2. Department of Quantitative Methods, Harvard School of Public Health, Boston, Massachusetts, USA.
  3. Division of Infectious Disease, Department of Pediatrics, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
  4. Division of Laboratory, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
  5. Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Tokyo, Japan.
  6. Division of Orthopedics, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.

PMID: 27005513 DOI: 10.1111/ped.12806

Abstract

Cases of infection with hypervirulent Klebsiella pneumoniae are gradually increasing in number, and cause life-threatening community-acquired infection even in immunocompetent patients. A 14-year-old boy developed septic hip arthritis due to hypervirulent K. pneumoniae (sequence type 23, serotype K1, magA positive). The patient initially seemed to have been successfully treated with antibiotics and surgical intervention, but septic arthritis developed into osteomyelitis of the femoral head and myositis, which required long-term antibiotic therapy and additional surgical intervention. This is the first pediatric case of hypervirulent K. pneumoniae septic hip arthritis. Treatment plans should mainly consist of antibiotic therapy and surgical intervention. Clinicians, even pediatricians, in developed countries should be aware of the increasing incidence of hypervirulent Klebsiella pneumoniae infection.

© 2016 Japan Pediatric Society.

Keywords: bacterial translocation; hypermucoviscosity; hypervirulent Klebsiella pneumoniae; septic arthritis; string test

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