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Wildenauer DB, Schwab SG, Maier W, et al. Searching for genes in Schizophrenia. Acta Neuropsychiatr. 1999;11(2):50-3doi: 10.1017/S0924270800036140.
Wildenauer, D. B., Schwab, S. G., Maier, W., & Lerer, B. (1999). Searching for genes in Schizophrenia. Acta neuropsychiatrica, 11(2), 50-3. https://doi.org/10.1017/S0924270800036140
Wildenauer, D B, et al. "Searching for genes in Schizophrenia." Acta neuropsychiatrica vol. 11,2 (1999): 50-3. doi: https://doi.org/10.1017/S0924270800036140
Wildenauer DB, Schwab SG, Maier W, Lerer B. Searching for genes in Schizophrenia. Acta Neuropsychiatr. 1999 Jun;11(2):50-3. doi: 10.1017/S0924270800036140. PMID: 26976252.
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Acta Neuropsychiatr. 1999 Jun;11(2):50-3. doi: 10.1017/S0924270800036140.

Searching for genes in Schizophrenia.

Acta neuropsychiatrica

D B Wildenauer, S G Schwab, W Maier, B Lerer

Affiliations

  1. Molecular Genetics Laboratory,Dept. of Psychiatry,University of Bonn.
  2. Dept. of Psychiatry,Hadassah-Hebrew University Medical Centre,Jerusalem,Israel.

PMID: 26976252 DOI: 10.1017/S0924270800036140

Abstract

Decades of research into the etiology of schizophrenia on a phenotypic level, i.e. studies of neuroanatomy, neuropathology, neurophysiology and other areas such as immunology have yielded only fragmentary results. A contribution of genetic factors, has been consistently shown, however, beginning with E. Kraepelin's pioneering studies at the turn of the century. Evidence has accumulated from family-, twin-, and adoption studies. Identical twins have a 48% risk of developing schizophrenia if one of them is affected. In contrast, a 17 % risk is reported for nonidentical twins. These rates are similar to other complex genetic disorders such as diabetes, hypertension and asthma. Advances in the genetic analysis of complex traits as well as progress in the Human Genome Project should provide a basis for uncovering the molecular causes of schizophrenic disorders and for investigating the neuropathology of this individually and socially devastating neuropsychiatrie disorder. There is no doubt, that discovery of the genetic variation associated with the illness would help in identifying specific targets for development of more effective, targeted treatments.

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