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Lei L, Zhang H, Zhang XB, et al. Consensus and conflict in invasive micropapillary carcinoma: a case report and review of the literature. J Gastrointest Oncol. 2016;7:S55-61doi: 10.3978/j.issn.2078-6891.2015.029.
Lei, L., Zhang, H., Zhang, X. B., Lonser, R., Thompson, K., & Raza, A. (2016). Consensus and conflict in invasive micropapillary carcinoma: a case report and review of the literature. Journal of gastrointestinal oncology, 7S55-61. https://doi.org/10.3978/j.issn.2078-6891.2015.029
Lei, Li, et al. "Consensus and conflict in invasive micropapillary carcinoma: a case report and review of the literature." Journal of gastrointestinal oncology vol. 7 (2016): S55-61. doi: https://doi.org/10.3978/j.issn.2078-6891.2015.029
Lei L, Zhang H, Zhang XB, Lonser R, Thompson K, Raza A. Consensus and conflict in invasive micropapillary carcinoma: a case report and review of the literature. J Gastrointest Oncol. 2016 Apr;7:S55-61. doi: 10.3978/j.issn.2078-6891.2015.029. PMID: 27034813; PMCID: PMC4783610.
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J Gastrointest Oncol. 2016 Apr;7:S55-61. doi: 10.3978/j.issn.2078-6891.2015.029.

Consensus and conflict in invasive micropapillary carcinoma: a case report and review of the literature.

Journal of gastrointestinal oncology

Li Lei, Huina Zhang, Xinhai Bob Zhang, Roland Lonser, Kevin Thompson, Anwar Raza

Affiliations

  1. Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, CA 92354, USA.

PMID: 27034813 PMCID: PMC4783610 DOI: 10.3978/j.issn.2078-6891.2015.029

Abstract

Invasive micropapillary carcinoma (IMPC) is an aggressive histologic subtype of adenocarcinoma that has been gaining increased attention over the past twenty years. It is important to recognize IMPC due to its strong association with early lymphovascular invasion (LVI), high risk of lymph node metastasis, perineural invasion and poor prognosis. Controversies regarding IMPC include differentiating from retraction artifact and mimics, clinical significance of proportion of micropapillary component (MC), pathogenesis, biologic nature of the entity and consequently terminology, etc. We herein present a case of rectal IMPC arising from a tubulovillous adenoma. Since HER2 over-expression has been reported in IMPC of the breast and the bladder but never in the colorectum, given the availability of HER2 targeted therapy, HER2 protein expression in our case is examined by immunohistochemical study which shows weak incomplete membrane staining in less than 5% of cells. Literature is reviewed with emphasis on colorectal IMPC as well as aforementioned controversial topics. In summary, more study is needed to resolve the conflicts and build consensus on IMPC.

Keywords: Micropapillary; adenocarcinoma; colorectum; retraction artifact; reversed polarity

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