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Shukla P, Fatima U, Malaviya AK. Histomorphological and Immunohistochemical Reappraisal of Cutaneous Adnexal Tumours: A Hospital Based Study. Scientifica (Cairo). 2016;2016:2173427doi: 10.1155/2016/2173427.
Shukla, P., Fatima, U., & Malaviya, A. K. (2016). Histomorphological and Immunohistochemical Reappraisal of Cutaneous Adnexal Tumours: A Hospital Based Study. Scientifica, 20162173427. https://doi.org/10.1155/2016/2173427
Shukla, Prakriti, et al. "Histomorphological and Immunohistochemical Reappraisal of Cutaneous Adnexal Tumours: A Hospital Based Study." Scientifica vol. 2016 (2016): 2173427. doi: https://doi.org/10.1155/2016/2173427
Shukla P, Fatima U, Malaviya AK. Histomorphological and Immunohistochemical Reappraisal of Cutaneous Adnexal Tumours: A Hospital Based Study. Scientifica (Cairo). 2016;2016:2173427. doi: 10.1155/2016/2173427. Epub 2016 Feb 29. PMID: 27034895; PMCID: PMC4789832.
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Scientifica (Cairo). 2016;2016:2173427. doi: 10.1155/2016/2173427. Epub 2016 Feb 29.

Histomorphological and Immunohistochemical Reappraisal of Cutaneous Adnexal Tumours: A Hospital Based Study.

Scientifica

Prakriti Shukla, Uroos Fatima, Anil K Malaviya

Affiliations

  1. Department of Pathology, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India; Bhopal Memorial Hospital and Research Center, Raisen Road, Bhopal, Madhya Pradesh 462038, India.
  2. Department of Pathology, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.

PMID: 27034895 PMCID: PMC4789832 DOI: 10.1155/2016/2173427

Abstract

Background. Diagnosing adnexal tumours of the skin is a challenge due to their wide variety, infrequent occurrence in practice, and confusing morphological picture. Aims and Objectives. The present study aims to observe the spectrum of adnexal tumours at our institute and to evaluate them based on histomorphological, histochemical, and immunohistochemical methods either alone or in combination for proper identification and classification. Materials and Methods. A partly retrospective and partly prospective study was conducted on adnexal skin tumours over a period of 6 years. Relevant clinical profile was recorded. Histopathological examination was carried out and special stains were applied as and when required. Immunohistochemistry was performed where diagnosis with routine stains was not possible. Results. A total of 150 skin tumour biopsies were received. There were 87 keratotic tumours, 39 adnexal tumours, and 24 melanocytic tumours. Amongst the adnexal tumours, 51.3% eccrine, 30.8% follicular, and 17.9% sebaceous tumours were seen. In five cases, histological diagnosis was troublesome where immunohistochemistry helped in making final diagnosis. Limitations. The sample size is small. Conclusion. Histomorphology is confirmatory in majority of the adnexal tumours but few rare lesions that mimic internal malignancy require a panel of immunomarkers to rule out other possible differentials.

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