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Li X, Xie X, Liu Y. Gold(I)-Catalyzed Cascade Hydroarylation/Cycloaromatization to Indolizines via Pyridine Ring Construction. J Org Chem. 2016;81(9):3688-99doi: 10.1021/acs.joc.6b00346.
Li, X., Xie, X., & Liu, Y. (2016). Gold(I)-Catalyzed Cascade Hydroarylation/Cycloaromatization to Indolizines via Pyridine Ring Construction. The Journal of organic chemistry, 81(9), 3688-99. https://doi.org/10.1021/acs.joc.6b00346
Li, Xiangdong, et al. "Gold(I)-Catalyzed Cascade Hydroarylation/Cycloaromatization to Indolizines via Pyridine Ring Construction." The Journal of organic chemistry vol. 81,9 (2016): 3688-99. doi: https://doi.org/10.1021/acs.joc.6b00346
Li X, Xie X, Liu Y. Gold(I)-Catalyzed Cascade Hydroarylation/Cycloaromatization to Indolizines via Pyridine Ring Construction. J Org Chem. 2016 May 06;81(9):3688-99. doi: 10.1021/acs.joc.6b00346. Epub 2016 Apr 08. PMID: 27035285.
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J Org Chem. 2016 May 06;81(9):3688-99. doi: 10.1021/acs.joc.6b00346. Epub 2016 Apr 08.

Gold(I)-Catalyzed Cascade Hydroarylation/Cycloaromatization to Indolizines via Pyridine Ring Construction.

The Journal of organic chemistry

Xiangdong Li, Xin Xie, Yuanhong Liu

Affiliations

  1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, People's Republic of China.

PMID: 27035285 DOI: 10.1021/acs.joc.6b00346

Abstract

An efficient and atom-economic method for the synthesis of multisubstituted indolizines via gold-catalyzed cascade hydroarylation/cycloaromatization reaction of α-(N-pyrrolyl)ketones with alkynes is described. The reaction is realized through the construction of the pyridine ring of indolizines, which allows the regioselective incorporation of a wide range of functionalities on the pyridine unit.

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