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Al-Dughaishi T, Al-Waili K, Banerjee Y, et al. Successful Direct Adsorption of Lipoproteins (DALI) Apheresis During Pregnancy in an Omani Woman with Homozygous Familial Hypercholesterolemia. Open Cardiovasc Med J. 2015;9:114-7doi: 10.2174/1874192401509010114.
Al-Dughaishi, T., Al-Waili, K., Banerjee, Y., Sheik, S., Al-Sabti, H., Al-Zakwani, I., Al-Mukhaini, S., Al Wahaibi, K., Al-Hinai, A. T., & Al-Rasadi, K. (2015). Successful Direct Adsorption of Lipoproteins (DALI) Apheresis During Pregnancy in an Omani Woman with Homozygous Familial Hypercholesterolemia. The open cardiovascular medicine journal, 9114-7. https://doi.org/10.2174/1874192401509010114
Al-Dughaishi, Tamima, et al. "Successful Direct Adsorption of Lipoproteins (DALI) Apheresis During Pregnancy in an Omani Woman with Homozygous Familial Hypercholesterolemia." The open cardiovascular medicine journal vol. 9 (2015): 114-7. doi: https://doi.org/10.2174/1874192401509010114
Al-Dughaishi T, Al-Waili K, Banerjee Y, Sheik S, Al-Sabti H, Al-Zakwani I, Al-Mukhaini S, Al Wahaibi K, Al-Hinai AT, Al-Rasadi K. Successful Direct Adsorption of Lipoproteins (DALI) Apheresis During Pregnancy in an Omani Woman with Homozygous Familial Hypercholesterolemia. Open Cardiovasc Med J. 2015 Dec 29;9:114-7. doi: 10.2174/1874192401509010114. eCollection 2015. PMID: 27006714; PMCID: PMC4768655.
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Open Cardiovasc Med J. 2015 Dec 29;9:114-7. doi: 10.2174/1874192401509010114. eCollection 2015.

Successful Direct Adsorption of Lipoproteins (DALI) Apheresis During Pregnancy in an Omani Woman with Homozygous Familial Hypercholesterolemia.

The open cardiovascular medicine journal

Tamima Al-Dughaishi, Khalid Al-Waili, Yajnavalka Banerjee, Shahila Sheik, Hilal Al-Sabti, Ibrahim Al-Zakwani, Suad Al-Mukhaini, Khalifa Al Wahaibi, Ali T Al-Hinai, Khalid Al-Rasadi

Affiliations

  1. Department of Obstetrics & Gynecology, Sultan Qaboos University Hospital, Muscat, Oman.
  2. Department of Clinical Biochemistry, Sultan Qaboos University Hospital, Muscat, Oman.
  3. Department of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman.
  4. Department of Surgery, Cardiothoracic Unit, Sultan Qaboos University Hospital, Muscat, Oman.
  5. Department of Pharmacology and Clinical Pharmacy, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman; Gulf Health Research, Muscat, Oman.
  6. Department of Nursing, Sultan Qaboos University Hospital, Muscat, Oman.
  7. Department of Surgery, Vascular Unit, Sultan Qaboos University Hospital, Muscat, Oman.
  8. Ministry of Health, Muscat, Oman.

PMID: 27006714 PMCID: PMC4768655 DOI: 10.2174/1874192401509010114

Abstract

We report our experience with Direct Adsorption of Lipoproteins (DALI) apheresis in an Omani pregnant woman affected by homozygous familial hypercholesterolemia. To the best of our knowledge this is the first successful pregnancy treated with DALI apheresis. The patient had a history of coronary artery disease, supra-aortic valvular stenosis and severe carotid artery disease with right carotid artery stenting. She was on a regular biweekly DALI apheresis since 2008. In May 2013, she became pregnant and rosuvastatin and ezetimibe were stopped while she continued on DALI apheresis biweekly. This treatment during pregnancy was successful with no major complications. The average low-density lipoprotein cholesterol reduction during therapy was 50%. She spontaneously delivered a healthy male infant (2,400 g) at 37 weeks. We showed that DALI apheresis therapy was safe during pregnancy with a good outcome for both mother and neonate.

Keywords: Familial hypercholesterolemia; LDL-apheresis; low density lipoprotein receptor; pregnancy; xanthoma

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