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Harton J, Jin L, Hahn A, et al. Immunological Functions of the Membrane Proximal Region of MHC Class II Molecules. F1000Res. 2016;5doi: 10.12688/f1000research.7610.1.
Harton, J., Jin, L., Hahn, A., & Drake, J. (2016). Immunological Functions of the Membrane Proximal Region of MHC Class II Molecules. F1000Research, 5. https://doi.org/10.12688/f1000research.7610.1
Harton, Jonathan, et al. "Immunological Functions of the Membrane Proximal Region of MHC Class II Molecules." F1000Research vol. 5 (2016). doi: https://doi.org/10.12688/f1000research.7610.1
Harton J, Jin L, Hahn A, Drake J. Immunological Functions of the Membrane Proximal Region of MHC Class II Molecules. F1000Res. 2016 Mar 17;5. doi: 10.12688/f1000research.7610.1. eCollection 2016. PMID: 27006762; PMCID: PMC4798158.
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F1000Res. 2016 Mar 17;5. doi: 10.12688/f1000research.7610.1. eCollection 2016.

Immunological Functions of the Membrane Proximal Region of MHC Class II Molecules.

F1000Research

Jonathan Harton, Lei Jin, Amy Hahn, Jim Drake

Affiliations

  1. Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, 12208-3479, USA.
  2. Transplantation Immunology Laboratory, Albany Medical College, Albany, New York, 12208-3479, USA.

PMID: 27006762 PMCID: PMC4798158 DOI: 10.12688/f1000research.7610.1

Abstract

Major histocompatibility complex (MHC) class II molecules present exogenously derived antigen peptides to CD4 T cells, driving activation of naïve T cells and supporting CD4-driven immune functions. However, MHC class II molecules are not inert protein pedestals that simply bind and present peptides. These molecules also serve as multi-functional signaling molecules delivering activation, differentiation, or death signals (or a combination of these) to B cells, macrophages, as well as MHC class II-expressing T cells and tumor cells. Although multiple proteins are known to associate with MHC class II, interaction with STING (stimulator of interferon genes) and CD79 is essential for signaling. In addition, alternative transmembrane domain pairing between class II α and β chains influences association with membrane lipid sub-domains, impacting both signaling and antigen presentation. In contrast to the membrane-distal region of the class II molecule responsible for peptide binding and T-cell receptor engagement, the membrane-proximal region (composed of the connecting peptide, transmembrane domain, and cytoplasmic tail) mediates these "non-traditional" class II functions. Here, we review the literature on the function of the membrane-proximal region of the MHC class II molecule and discuss the impact of this aspect of class II immunobiology on immune regulation and human disease.

Keywords: Class II connecting peptide; Myasthenia gravis; immubiology; membrane distal region; membrane proximal region

References

  1. Semin Respir Crit Care Med. 2010 Aug;31(4):380-9 - PubMed
  2. J Immunol. 1997 Oct 15;159(8):3792-8 - PubMed
  3. J Biol Chem. 2009 Mar 13;284(11):7007-16 - PubMed
  4. Int Immunol. 1994 Oct;6(10):1457-65 - PubMed
  5. Curr Opin Immunol. 2004 Feb;16(1):103-7 - PubMed
  6. Science. 2001 Feb 23;291(5508):1537-40 - PubMed
  7. J Biol Chem. 2004 Apr 30;279(18):18472-80 - PubMed
  8. Nat Immunol. 2002 Jan;3(1):61-8 - PubMed
  9. J Immunol. 2004 Aug 1;173(3):1876-86 - PubMed
  10. Nat Genet. 2012 Jan 29;44(3):291-6 - PubMed
  11. Immunity. 1995 Sep;3(3):349-58 - PubMed
  12. J Autoimmun. 2008 Nov;31(3):295-300 - PubMed
  13. J Biol Chem. 2012 Aug 17;287(34):28779-89 - PubMed
  14. J Immunol. 1995 Aug 15;155(4):1737-45 - PubMed
  15. Hum Immunol. 2006 Apr-May;67(4-5):352-8 - PubMed
  16. Clin Neurol Neurosurg. 2013 Jan;115(1):32-6 - PubMed
  17. J Immunol. 1994 Oct 15;153(8):3398-407 - PubMed
  18. Mol Biosyst. 2010 Sep;6(9):1650-61 - PubMed
  19. J Biol Chem. 2015 Nov 6;290(45):27101-12 - PubMed
  20. Eur J Immunol. 2001 Mar;31(3):841-50 - PubMed
  21. J Immunol. 2005 Feb 1;174(3):1306-16 - PubMed
  22. J Immunol. 1986 Nov 1;137(9):3002-5 - PubMed
  23. J Immunol. 2006 Jan 15;176(2):827-38 - PubMed
  24. J Immunol. 1998 Oct 1;161(7):3282-91 - PubMed
  25. J Biol Chem. 2014 Apr 25;289(17):11695-703 - PubMed
  26. Science. 1992 Oct 23;258(5082):659-62 - PubMed
  27. J Cell Biol. 1989 Dec;109(6 Pt 2):3325-31 - PubMed
  28. J Immunol. 2012 May 15;188(10 ):4959-70 - PubMed
  29. J Neuroimmunol. 2012 Jun 15;247(1-2):81-5 - PubMed
  30. J Autoimmun. 2015 Nov;64:13-25 - PubMed
  31. Expert Rev Clin Immunol. 2012 Jan;8(1):55-62 - PubMed
  32. J Immunol. 2011 Jun 15;186(12):6710-7 - PubMed
  33. Curr Opin Neurol. 2009 Jun;22(3):219-25 - PubMed
  34. J Biol Chem. 1984 Jun 10;259(11):7230-8 - PubMed
  35. Front Biosci (Landmark Ed). 2013 Jun 01;18:1080-7 - PubMed
  36. J Exp Med. 1981 Jul 1;154(1):188-92 - PubMed
  37. J Immunol. 1987 Apr 1;138(7):2345-52 - PubMed
  38. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20188-93 - PubMed
  39. Int J Immunogenet. 2011 Feb;38(1):55-62 - PubMed
  40. J Cell Sci. 2005 Oct 15;118(Pt 20):4679-87 - PubMed
  41. J Immunol. 1991 Aug 15;147(4):1107-14 - PubMed
  42. Immunol Lett. 2008 Mar 15;116(2):184-94 - PubMed
  43. Eur J Immunol. 2009 Jan;39(1):96-112 - PubMed
  44. Immunol Rev. 2002 Nov;189:136-51 - PubMed
  45. Mol Cells. 2010 Mar;29(3):229-32 - PubMed
  46. Tissue Antigens. 2006 Aug;68(2):167-72 - PubMed
  47. Front Immunol. 2013 Oct 10;4:321 - PubMed
  48. Int Immunol. 1995 Apr;7(4):665-77 - PubMed
  49. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6297-301 - PubMed
  50. Curr Opin Neurobiol. 2013 Oct;23(5):767-73 - PubMed
  51. J Lipid Res. 2013 Nov;54(11):3106-15 - PubMed
  52. Clin Gastroenterol Hepatol. 2005 Sep;3(9):843-51 - PubMed
  53. Int Immunol. 2003 Oct;15(10):1249-63 - PubMed
  54. Front Immunol. 2013 Nov 13;4:369 - PubMed
  55. Int Immunol. 2000 Sep;12(9):1319-28 - PubMed
  56. Nat Rev Rheumatol. 2015 Aug;11(8):450-61 - PubMed
  57. PLoS Biol. 2005 Jun;3(6):e150 - PubMed
  58. Int J Immunogenet. 2014 Feb;41(1):1-12 - PubMed
  59. Eur J Immunol. 1995 Dec;25(12):3249-55 - PubMed
  60. EMBO J. 2007 Feb 7;26(3):846-54 - PubMed
  61. Mol Cell Biol. 2008 Aug;28(16):5014-26 - PubMed

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