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Carmona-Negrón JA, Cádiz ME, Moore CE, et al. New platinum(II) complexes with benzo-thia-zole ligands. Acta Crystallogr E Crystallogr Commun. 2016;72:412-6doi: 10.1107/S2056989016002826.
Carmona-Negrón, J. A., Cádiz, M. E., Moore, C. E., Rheingold, A. L., & Meléndez, E. (2016). New platinum(II) complexes with benzo-thia-zole ligands. Acta crystallographica. Section E, Crystallographic communications, 72412-6. https://doi.org/10.1107/S2056989016002826
Carmona-Negrón, José A, et al. "New platinum(II) complexes with benzo-thia-zole ligands." Acta crystallographica. Section E, Crystallographic communications vol. 72 (2016): 412-6. doi: https://doi.org/10.1107/S2056989016002826
Carmona-Negrón JA, Cádiz ME, Moore CE, Rheingold AL, Meléndez E. New platinum(II) complexes with benzo-thia-zole ligands. Acta Crystallogr E Crystallogr Commun. 2016 Feb 24;72:412-6. doi: 10.1107/S2056989016002826. eCollection 2016 Mar 01. PMID: 27006819; PMCID: PMC4778805.
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Acta Crystallogr E Crystallogr Commun. 2016 Feb 24;72:412-6. doi: 10.1107/S2056989016002826. eCollection 2016 Mar 01.

New platinum(II) complexes with benzo-thia-zole ligands.

Acta crystallographica. Section E, Crystallographic communications

José A Carmona-Negrón, Mayra E Cádiz, Curtis E Moore, Arnold L Rheingold, Enrique Meléndez

Affiliations

  1. University of Puerto Rico, Department of Chemistry, PO Box 9019, Mayaguez, PR 00681, Puerto Rico.
  2. University of California-San Diego, Department of Chemistry, Urey Hall 5128, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.

PMID: 27006819 PMCID: PMC4778805 DOI: 10.1107/S2056989016002826

Abstract

Four new platinum(II) complexes, namely tetra-ethyl-ammonium tri-bromido-(2-methyl-1,3-benzo-thia-zole-κN)platinate(II), [NEt4][PtBr3(C8H7NS)] (1), tetra-ethyl-ammonium tri-bromido-(6-meth-oxy-2-methyl-1,3-benzo-thia-zole-κN)platinate(II), [NEt4][PtBr3(C9H9NOS)] (2), tetra-ethyl-ammonium tri-bromido-(2,5,6-trimethyl-1,3-benzo-thia-zole-κN)platinate(II), [NEt4][PtBr3(C10H11NS)] (3), and tetra-ethyl-ammonium tri-bromido-(2-methyl-5-nitro-1,3-benzo-thia-zole-κN)platinate(II), [NEt4][PtBr3(C8H6N2O2S)] (4), have been synthesized and structurally characterized by single-crystal X-ray diffraction techniques. These species are precursors of compounds with potential application in cancer chemotherapy. All four platinum(II) complexes adopt the expected square-planar coordination geometry, and the benzo-thia-zole ligand is engaged in bonding to the metal atom through the imine N atom (Pt-N). The Pt-N bond lengths are normal: 2.035 (5), 2.025 (4), 2.027 (5) and 2.041 (4) Å for complexes 1, 2, 3 and 4, respectively. The benzo-thia-zole ligands are positioned out of the square plane, with dihedral angles ranging from 76.4 (4) to 88.1 (4)°. The NEt4 cation in 3 is disordered with 0.57/0.43 occupancies.

Keywords: anti­cancer; benzo­thia­zole; cisplatin; crystal structure; platinum(II)

References

  1. Eur J Med Chem. 2012 Aug;54:447-62 - PubMed
  2. Acta Crystallogr A Found Adv. 2015 Jan;71(Pt 1):3-8 - PubMed
  3. Acta Crystallogr C Struct Chem. 2015 Jan;71(Pt 1):3-8 - PubMed
  4. Acta Crystallogr C. 1988 Sep 15;44 ( Pt 9):1554-7 - PubMed

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