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Abers MS, Ghebremichael MS, Timmons AK, et al. A Critical Reappraisal of Prolonged Neutropenia as a Risk Factor for Invasive Pulmonary Aspergillosis. Open Forum Infect Dis. 2016;3(1):ofw036doi: 10.1093/ofid/ofw036.
Abers, M. S., Ghebremichael, M. S., Timmons, A. K., Warren, H. S., Poznansky, M. C., & Vyas, J. M. (2016). A Critical Reappraisal of Prolonged Neutropenia as a Risk Factor for Invasive Pulmonary Aspergillosis. Open forum infectious diseases, 3(1), ofw036. https://doi.org/10.1093/ofid/ofw036
Abers, Michael S, et al. "A Critical Reappraisal of Prolonged Neutropenia as a Risk Factor for Invasive Pulmonary Aspergillosis." Open forum infectious diseases vol. 3,1 (2016): ofw036. doi: https://doi.org/10.1093/ofid/ofw036
Abers MS, Ghebremichael MS, Timmons AK, Warren HS, Poznansky MC, Vyas JM. A Critical Reappraisal of Prolonged Neutropenia as a Risk Factor for Invasive Pulmonary Aspergillosis. Open Forum Infect Dis. 2016 Feb 12;3(1):ofw036. doi: 10.1093/ofid/ofw036. eCollection 2016 Jan. PMID: 27006961; PMCID: PMC4800458.
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Open Forum Infect Dis. 2016 Feb 12;3(1):ofw036. doi: 10.1093/ofid/ofw036. eCollection 2016 Jan.

A Critical Reappraisal of Prolonged Neutropenia as a Risk Factor for Invasive Pulmonary Aspergillosis.

Open forum infectious diseases

Michael S Abers, Musie S Ghebremichael, Allison K Timmons, H Shaw Warren, Mark C Poznansky, Jatin M Vyas

Affiliations

  1. Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital; Harvard Medical School.
  2. Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital; Harvard Medical School; Ragon Institute of MGH, MIT and Harvard, Cambridge.
  3. Division of Infectious Diseases, Department of Medicine , Massachusetts General Hospital.
  4. Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital; Harvard Medical School; Vaccine and Immunotherapy Center, MGH, Boston, Massachusetts.

PMID: 27006961 PMCID: PMC4800458 DOI: 10.1093/ofid/ofw036

Abstract

Prolonged neutropenia is generally thought to be the major factor for invasive pulmonary aspergillosis (IPA). In the present study, we characterize the frequency, severity, and duration of neutropenia that immediately precedes IPA. Prolonged neutropenia was identified in only one third of all IPA cases and occurred exclusively in hematologic patients.

Keywords: Aspergillus; immunosuppression; invasive aspergillosis; invasive fungal infection; neutropenia

References

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