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Re R, Contini D, Zucchelli L, et al. Effect of a thin superficial layer on the estimate of hemodynamic changes in a two-layer medium by time domain NIRS. Biomed Opt Express. 2016;7(2):264-78doi: 10.1364/BOE.7.000264.
Re, R., Contini, D., Zucchelli, L., Torricelli, A., & Spinelli, L. (2016). Effect of a thin superficial layer on the estimate of hemodynamic changes in a two-layer medium by time domain NIRS. Biomedical optics express, 7(2), 264-78. https://doi.org/10.1364/BOE.7.000264
Re, Rebecca, et al. "Effect of a thin superficial layer on the estimate of hemodynamic changes in a two-layer medium by time domain NIRS." Biomedical optics express vol. 7,2 (2016): 264-78. doi: https://doi.org/10.1364/BOE.7.000264
Re R, Contini D, Zucchelli L, Torricelli A, Spinelli L. Effect of a thin superficial layer on the estimate of hemodynamic changes in a two-layer medium by time domain NIRS. Biomed Opt Express. 2016 Jan 05;7(2):264-78. doi: 10.1364/BOE.7.000264. eCollection 2016 Feb 01. PMID: 26977338; PMCID: PMC4771447.
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Biomed Opt Express. 2016 Jan 05;7(2):264-78. doi: 10.1364/BOE.7.000264. eCollection 2016 Feb 01.

Effect of a thin superficial layer on the estimate of hemodynamic changes in a two-layer medium by time domain NIRS.

Biomedical optics express

Rebecca Re, Davide Contini, Lucia Zucchelli, Alessandro Torricelli, Lorenzo Spinelli

Affiliations

  1. Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milan, Italy.
  2. IFN-CNR, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.

PMID: 26977338 PMCID: PMC4771447 DOI: 10.1364/BOE.7.000264

Abstract

In order to study hemodynamic changes involved in muscular metabolism by means of time domain fNIRS, we need to discriminate in the measured signal contributions coming from different depths. Muscles are, in fact, typically located under other tissues, e.g. skin and fat. In this paper, we study the possibility to exploit a previously proposed method for analyzing time-resolved fNIRS measurements in a two-layer structure with a thin superficial layer. This method is based on the calculation of the time-dependent mean partial pathlengths. We validated it by simulating venous and arterial arm cuff occlusions and then applied it on in vivo measurements.

Keywords: (170.1470) Blood or tissue constituent monitoring; (170.2655) Functional monitoring and imaging; (170.5280) Photon migration; (170.6920) Time-resolved imaging

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