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Mihailovich M, Bonaldi T. MS-analysis of SILAC-labeled MYC-driven B lymphoma cells overexpressing miR-17-19b. Data Brief. 2016;7:349-53doi: 10.1016/j.dib.2016.02.031.
Mihailovich, M., & Bonaldi, T. (2016). MS-analysis of SILAC-labeled MYC-driven B lymphoma cells overexpressing miR-17-19b. Data in brief, 7349-53. https://doi.org/10.1016/j.dib.2016.02.031
Mihailovich, Marija, and Bonaldi, Tiziana. "MS-analysis of SILAC-labeled MYC-driven B lymphoma cells overexpressing miR-17-19b." Data in brief vol. 7 (2016): 349-53. doi: https://doi.org/10.1016/j.dib.2016.02.031
Mihailovich M, Bonaldi T. MS-analysis of SILAC-labeled MYC-driven B lymphoma cells overexpressing miR-17-19b. Data Brief. 2016 Feb 24;7:349-53. doi: 10.1016/j.dib.2016.02.031. eCollection 2016 Jun. PMID: 26977435; PMCID: PMC4781929.
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Data Brief. 2016 Feb 24;7:349-53. doi: 10.1016/j.dib.2016.02.031. eCollection 2016 Jun.

MS-analysis of SILAC-labeled MYC-driven B lymphoma cells overexpressing miR-17-19b.

Data in brief

Marija Mihailovich, Tiziana Bonaldi

Affiliations

  1. Department of Experimental Oncology, European Institute of Oncology, Milan 20139, Italy.

PMID: 26977435 PMCID: PMC4781929 DOI: 10.1016/j.dib.2016.02.031

Abstract

Micro RNAs (miRNAs) are small non-coding RNAs, which dampen gene expression by repressing translation and/or inducing degradation of target-mRNAs. Although the role of miR-17-19b (a truncated version of miR-17-92 cluster) is well documented in MYC-driven B cell lymphomagenesis, little is known about the function of the cluster in the maintenance of full-blown lymphomas. We employed SILAC-based quantitative proteomics to identify miR-17-19b targets upon a mild overexpression of the cluster in B cell lymphomas, established from λ-MYC transgenic mice. The proteomics data described in detail in this study, whose follow up analysis with MaxQuant algorithm is part of the recent publication (Mihailovich et al., 2015) [1], are deposited to the ProteomeXchange Consortium via the PRIDE partner repository, with the accession code PRIDE: PXD002810.

Keywords: B cell lymphoma; MYC; Mass spectrometry; MiR-17-92; MiRNA targets; Quantitative proteomics; SILAC

References

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