Display options
Cite
Osorio S, Casado LF, Giraldo P, et al. Leucemia mieloide crónica en España: sus características de presentación han cambiado. Sección española del registro poblacional EUTOS. Chronic myeloid leukaemia in Spain: Its presentation characteristics have changed. Spanish section of the EUTOS population-based registry. Rev Clin Esp (Barc). 2016;216(6):293-300doi: 10.1016/j.rce.2016.03.001.
Osorio, S., Casado, L. F., Giraldo, P., Maestro, B., Andrade, M., Redondo, S., García-Gutiérrez, V., Ayala, R., Garcia, N., & Steegmann, J. L. (2016). Leucemia mieloide crónica en España: sus características de presentación han cambiado. Sección española del registro poblacional EUTOS. Chronic myeloid leukaemia in Spain: Its presentation characteristics have changed. Spanish section of the EUTOS population-based registry. Revista clinica espanola, 216(6), 293-300. https://doi.org/10.1016/j.rce.2016.03.001
Osorio, S, et al. "Leucemia mieloide crónica en España: sus características de presentación han cambiado. Sección española del registro poblacional EUTOS." Chronic myeloid leukaemia in Spain: Its presentation characteristics have changed. Spanish section of the EUTOS population-based registry. Revista clinica espanola vol. 216,6 (2016): 293-300. doi: https://doi.org/10.1016/j.rce.2016.03.001
Osorio S, Casado LF, Giraldo P, Maestro B, Andrade M, Redondo S, García-Gutiérrez V, Ayala R, Garcia N, Steegmann JL. Leucemia mieloide crónica en España: sus características de presentación han cambiado. Sección española del registro poblacional EUTOS. Chronic myeloid leukaemia in Spain: Its presentation characteristics have changed. Spanish section of the EUTOS population-based registry. Rev Clin Esp (Barc). 2016 Aug-Sep;216(6):293-300. doi: 10.1016/j.rce.2016.03.001. Epub 2016 Apr 06. Spanish. PMID: 27061504.
Copy Download .nbib Format: NLM
Share it on

Rev Clin Esp (Barc). 2016 Aug-Sep;216(6):293-300. doi: 10.1016/j.rce.2016.03.001. Epub 2016 Apr 06.

Chronic myeloid leukaemia in Spain: Its presentation characteristics have changed. Spanish section of the EUTOS population-based registry.

Revista clinica espanola

[Article in Spanish]
S Osorio, L F Casado, P Giraldo, B Maestro, M Andrade, S Redondo, V García-Gutiérrez, R Ayala, N Garcia, J L Steegmann

Affiliations

  1. Servicio de Hematología, Hospital Gregorio Marañón, Madrid, España. Electronic address: [email protected].
  2. Servicio de Hematología, Hospital Virgen de la Salud, Toledo, España.
  3. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Zaragoza, España.
  4. Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa (IIS-IP), Madrid, España.
  5. Servicio de Hematología, Hospital Miguel Servet, Zaragoza, España.
  6. Servicio de Hematología, Hospital Gregorio Marañón, Madrid, España.
  7. Servicio de Hematología, Hospital Ramón y Cajal, Madrid, España.
  8. Servicio de Hematología, Hospital 12 de Octubre, Madrid, España.

PMID: 27061504 DOI: 10.1016/j.rce.2016.03.001

Abstract

OBJECTIVES: To provide more reliable data on the epidemiology of chronic myeloid leukaemia (CML) in Spain than are currently available.

MATERIAL AND METHODS: The EUTOS population-based project of European LeukemiaNet is a population registry of new CML cases in patients 18 years of age or older from 22 European areas. The Spanish section included the autonomous communities of Madrid, Castilla-La Mancha and Aragon, from 1-2-2010 to 31-12-2012.

RESULTS: A total of 250 cases were recorded in 35 months. The overall incidence was 1.08 cases/10(5) inhabitants-year, with a predominance of men (58%) and clear differences among the communities. The incidence standardised by age was similar (overall, 1.04; men, 1.31; women, 0.81). The median age was 54 years. The incidence increased with age, reaching a peak at>65 years, although 31.7% of cases appeared between the ages of 20 and 44 years. Four percent of cases were diagnosed in advanced stages (2.4% in accelerated phase, 1.6% in blast crisis), 56% were asymptomatic, 38% had splenomegaly, and the Sokal score was high in 11% (lower than what was previously reflected in the literature).

CONCLUSIONS: The current incidence of CML in Spain is higher than previously reported and similar to that of the European studies. Unlike the classical descriptions, CML presented mostly in asymptomatic form, with no splenomegaly, less leucocytosis and in stages with better prognosis.

Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.

Keywords: Chronic myeloid leukaemia; Epidemiology; Epidemiología; España; Leucemia mieloide crónica; Spain

Publication Types