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Horta RN, Kahl VF, Sarmento Mda S, et al. Protective effects of acerola juice on genotoxicity induced by iron in vivo. Genet Mol Biol. 2016;39(1):122-8doi: 10.1590/1678-4685-GMB-2015-0157.
Horta, R. N., Kahl, V. F., Sarmento, M. d. a. . S., Nunes, M. F., Porto, C. R., Andrade, V. M., Ferraz, A. d. e. . B., & Silva, J. D. (2016). Protective effects of acerola juice on genotoxicity induced by iron in vivo. Genetics and molecular biology, 39(1), 122-8. https://doi.org/10.1590/1678-4685-GMB-2015-0157
Horta, Roberta Nunes, et al. "Protective effects of acerola juice on genotoxicity induced by iron in vivo." Genetics and molecular biology vol. 39,1 (2016): 122-8. doi: https://doi.org/10.1590/1678-4685-GMB-2015-0157
Horta RN, Kahl VF, Sarmento Mda S, Nunes MF, Porto CR, Andrade VM, Ferraz Ade B, Silva JD. Protective effects of acerola juice on genotoxicity induced by iron in vivo. Genet Mol Biol. 2016 Mar;39(1):122-8. doi: 10.1590/1678-4685-GMB-2015-0157. PMID: 27007905; PMCID: PMC4807388.
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Genet Mol Biol. 2016 Mar;39(1):122-8. doi: 10.1590/1678-4685-GMB-2015-0157.

Protective effects of acerola juice on genotoxicity induced by iron in vivo.

Genetics and molecular biology

Roberta Nunes Horta, Vivian Francilia Silva Kahl, Merielen da Silva Sarmento, Marisa Fernanda Silva Nunes, Carem Rejane Maglione Porto, Vanessa Moraes de Andrade, Alexandre de Barros Falcão Ferraz, Juliana Da Silva

Affiliations

  1. Centro de Ciências da Saúde, Universidade da Região da Campanha, Bagé, RS, Brazil.
  2. Laboratório de Genética Toxicológica, Universidade Luterana do Brasil, Canoas, RS, Brazil.
  3. Laboratório de Biologia Celular e Molecular, Unidade de Ciências de Saúde, Universidade do Estado de Santa Catarina, Criciúma, SC, Brazil.
  4. Laboratório do Farmacognosia e Fitoquímica, Universidade Luterana do Brasil, Canoas, RS, Brazil.

PMID: 27007905 PMCID: PMC4807388 DOI: 10.1590/1678-4685-GMB-2015-0157

Abstract

Metal ions such as iron can induce DNA damage by inducing reactive oxygen species (ROS) and oxidative stress. Vitamin C is one of the most widely consumed antioxidants worldwide, present in many fruits and vegetables, especially inMalpighia glabra L., popularly known as acerola, native to Brazil. Acerola is considered a functional fruit due to its high antioxidant properties and phenolic contents, and therefore is consumed to prevent diseases or as adjuvant in treatment strategies. Here, the influence of ripe and unripe acerola juices on iron genotoxicity was analyzed in vivo using the comet assay and micronucleus test. The comet assay results showed that acerola juice exerted no genotoxic or antigenotoxic activity. Neither ripe nor unripe acerola juices were mutagenic to animals treated with juices, in micronucleus test. However, when compared to iron group, the pre-treatment with acerola juices exerted antimutagenic activity, decreasing significantly micronucleus mean values in bone marrow. Stage of ripeness did not influence the interaction of acerola compounds with DNA, and both ripe and unripe acerola juices exerted protective effect over DNA damage generated by iron.

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