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Bellagamba BC, Abreu BR, Grivicich I, et al. Human mesenchymal stem cells are resistant to cytotoxic and genotoxic effects of cisplatin in vitro. Genet Mol Biol. 2016;39(1):129-34doi: 10.1590/1678-4685-GMB-2015-0057.
Bellagamba, B. C., Abreu, B. R., Grivicich, I., Markarian, C. F., Chem, E., Camassola, M., Nardi, N. B., & Dihl, R. R. (2016). Human mesenchymal stem cells are resistant to cytotoxic and genotoxic effects of cisplatin in vitro. Genetics and molecular biology, 39(1), 129-34. https://doi.org/10.1590/1678-4685-GMB-2015-0057
Bellagamba, Bruno Corrêa, et al. "Human mesenchymal stem cells are resistant to cytotoxic and genotoxic effects of cisplatin in vitro." Genetics and molecular biology vol. 39,1 (2016): 129-34. doi: https://doi.org/10.1590/1678-4685-GMB-2015-0057
Bellagamba BC, Abreu BR, Grivicich I, Markarian CF, Chem E, Camassola M, Nardi NB, Dihl RR. Human mesenchymal stem cells are resistant to cytotoxic and genotoxic effects of cisplatin in vitro. Genet Mol Biol. 2016 Mar;39(1):129-34. doi: 10.1590/1678-4685-GMB-2015-0057. PMID: 27007906; PMCID: PMC4807379.
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Genet Mol Biol. 2016 Mar;39(1):129-34. doi: 10.1590/1678-4685-GMB-2015-0057.

Human mesenchymal stem cells are resistant to cytotoxic and genotoxic effects of cisplatin in vitro.

Genetics and molecular biology

Bruno Corrêa Bellagamba, Bianca Regina Ribas de Abreu, Ivana Grivicich, Carolina Franke Markarian, Eduardo Chem, Melissa Camassola, Nance Beyer Nardi, Rafael Rodrigues Dihl

Affiliations

  1. Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  2. Universidade Luterana do Brasil, Canoas, RS, Brazil.
  3. Complexo Hospitalar Santa Casa de Porto Alegre, Porto Alegre, RS, Brazil.

PMID: 27007906 PMCID: PMC4807379 DOI: 10.1590/1678-4685-GMB-2015-0057

Abstract

Mesenchymal stem cells (MSCs) are known for their important properties involving multilineage differentiation potential., trophic factor secretion and localization along various organs and tissues. On the dark side, MSCs play a distinguished role in tumor microenvironments by differentiating into tumor-associated fibroblasts or supporting tumor growth via distinct mechanisms. Cisplatin (CIS) is a drug widely applied in the treatment of a large number of cancers and is known for its cytotoxic and genotoxic effects, both in vitro and in vivo. Here we assessed the effects of CIS on MSCs and the ovarian cancer cell line OVCAR-3, by MTT and comet assays. Our results demonstrated the resistance of MSCs to cell death and DNA damage induction by CIS, which was not observed when OVCAR-3 cells were exposed to this drug.

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