Display options
Cite
Ibero-Baraibar I, Suárez M, Arola-Arnal A, et al. Cocoa extract intake for 4 weeks reduces postprandial systolic blood pressure response of obese subjects, even after following an energy-restricted diet. Food Nutr Res. 2016;60:30449doi: 10.3402/fnr.v60.30449.
Ibero-Baraibar, I., Suárez, M., Arola-Arnal, A., Zulet, M. A., & Martinez, J. A. (2016). Cocoa extract intake for 4 weeks reduces postprandial systolic blood pressure response of obese subjects, even after following an energy-restricted diet. Food & nutrition research, 6030449. https://doi.org/10.3402/fnr.v60.30449
Ibero-Baraibar, Idoia, et al. "Cocoa extract intake for 4 weeks reduces postprandial systolic blood pressure response of obese subjects, even after following an energy-restricted diet." Food & nutrition research vol. 60 (2016): 30449. doi: https://doi.org/10.3402/fnr.v60.30449
Ibero-Baraibar I, Suárez M, Arola-Arnal A, Zulet MA, Martinez JA. Cocoa extract intake for 4 weeks reduces postprandial systolic blood pressure response of obese subjects, even after following an energy-restricted diet. Food Nutr Res. 2016 Mar 31;60:30449. doi: 10.3402/fnr.v60.30449. eCollection 2016. PMID: 27037002; PMCID: PMC4818356.
Copy Download .nbib Format: NLM
Share it on

Food Nutr Res. 2016 Mar 31;60:30449. doi: 10.3402/fnr.v60.30449. eCollection 2016.

Cocoa extract intake for 4 weeks reduces postprandial systolic blood pressure response of obese subjects, even after following an energy-restricted diet.

Food & nutrition research

Idoia Ibero-Baraibar, Manuel Suárez, Anna Arola-Arnal, M Angeles Zulet, J Alfredo Martinez

Affiliations

  1. Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain.
  2. Centre for Nutrition Research, Faculty of Pharmacy, University of Navarra, Pamplona, Spain.
  3. Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University, Tarragona, Spain.
  4. Centre Tecnològic de Nutrició i Salut (CTNS), TECNIO, CEICS, Reus, Spain.
  5. Physiopathology of Obesity and Nutrition, CIBERobn, Carlos III Health Research Institute, Madrid, Spain.
  6. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
  7. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain; [email protected].

PMID: 27037002 PMCID: PMC4818356 DOI: 10.3402/fnr.v60.30449

Abstract

BACKGROUND: Cardiometabolic profile is usually altered in obesity. Interestingly, the consumption of flavanol-rich foods might be protective against those metabolic alterations.

OBJECTIVE: To evaluate the postprandial cardiometabolic effects after the acute consumption of cocoa extract before and after 4 weeks of its daily intake. Furthermore, the bioavailability of cocoa extract was investigated.

DESIGN: Twenty-four overweight/obese middle-aged subjects participated in a 4-week intervention study. Half of the volunteers consumed a test meal enriched with 1.4 g of cocoa extract (415 mg flavanols), while the rest of the volunteers consumed the same meal without the cocoa extract (control group). Glucose and lipid profile, as well as blood pressure and cocoa metabolites in plasma, were assessed before and at 60, 120, and 180 min post-consumption, at the beginning of the study (Postprandial 1) and after following a 4-week 15% energy-restricted diet including meals containing or not containing the cocoa extract (Postprandial 2).

RESULTS: In the Postprandial 1 test, the area under the curve (AUC) of systolic blood pressure (SBP) was significantly higher in the cocoa group compared with the control group (p=0.007), showing significant differences after 120 min of intake. However, no differences between groups were observed at Postprandial 2. Interestingly, the reduction of postprandial AUC of SBP (AUC_Postprandial 2-AUC_Postprandial 1) was higher in the cocoa group (p=0.016). Furthermore, cocoa-derived metabolites were detected in plasma of the cocoa group, while the absence or significantly lower amounts of metabolites were found in the control group.

CONCLUSIONS: The daily consumption of cocoa extract within an energy-restricted diet for 4 weeks resulted in a greater reduction of postprandial AUC of SBP compared with the effect of energy-restricted diet alone and independently of body weight loss. These results suggest the role of cocoa flavanols on postprandial blood pressure homeostasis.

Keywords: bioavailability; blood pressure; cocoa; diet; polyphenols; weight loss

References

  1. Food Funct. 2014 Feb;5(2):364-74 - PubMed
  2. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Apr 15;877(11-12):1169-76 - PubMed
  3. Food Nutr Res. 2008;52:null - PubMed
  4. Mutagenesis. 2015 Jan;30(1):139-46 - PubMed
  5. Anal Bioanal Chem. 2009 Jul;394(6):1545-56 - PubMed
  6. Nutrients. 2013 Jul 31;5(8):2955-68 - PubMed
  7. Nutrients. 2014 Feb 21;6(2):844-80 - PubMed
  8. Cardiovasc Hematol Disord Drug Targets. 2014;14(1):50-63 - PubMed
  9. Eur J Nutr. 2013 Aug;52(5):1443-50 - PubMed
  10. Nutr Metab Cardiovasc Dis. 2014 Apr;24(4):416-22 - PubMed
  11. Am J Clin Nutr. 2002 Oct;76(4):798-804 - PubMed
  12. Metabolism. 2001 Dec;50(12):1499-504 - PubMed
  13. Diabetes Care. 1994 Feb;17(2):152-4 - PubMed
  14. Nutrients. 2013 Oct 18;5(10):4159-73 - PubMed
  15. Age (Dordr). 2015 Jun;37(3):9794 - PubMed
  16. Expert Opin Ther Targets. 2014 Apr;18(4):385-401 - PubMed
  17. J Hum Hypertens. 2010 Sep;24(9):568-76 - PubMed
  18. JAMA. 2003 Aug 27;290(8):1030-1 - PubMed
  19. Mol Nutr Food Res. 2013 Jun;57(6):948-61 - PubMed
  20. Handb Exp Pharmacol. 2011;(200):201-34 - PubMed
  21. Annu Rev Nutr. 2013;33:105-28 - PubMed
  22. Rev Endocr Metab Disord. 2013 Sep;14(3):219-27 - PubMed
  23. Nutr Metab Cardiovasc Dis. 2012 Dec;22(12):1046-53 - PubMed
  24. J Cardiovasc Pharmacol. 2007 Feb;49(2):74-80 - PubMed
  25. Food Funct. 2012 Aug;3(8):867-74 - PubMed
  26. Mol Nutr Food Res. 2013 Jun;57(6):962-73 - PubMed
  27. Hypertension. 2012 Sep;60(3):794-801 - PubMed
  28. Cochrane Database Syst Rev. 2012 Aug 15;(8):CD008893 - PubMed
  29. Clin Nutr. 2015 Oct;34(5):1010-7 - PubMed
  30. Annu Rev Food Sci Technol. 2011;2:125-51 - PubMed
  31. Psychopharmacology (Berl). 2013 Jul;228(1):109-18 - PubMed
  32. Br J Nutr. 2014 Jan 14;111(1):122-34 - PubMed
  33. Circ Res. 2015 Mar 13;116(6):991-1006 - PubMed
  34. Psychiatr Clin North Am. 2011 Dec;34(4):717-32 - PubMed
  35. Eur J Nutr. 2009 Sep;48(6):341-7 - PubMed
  36. Free Radic Biol Med. 2012 Aug 15;53(4):787-95 - PubMed
  37. Mol Nutr Food Res. 2014 Jan;58(1):33-48 - PubMed
  38. Food Funct. 2014 Mar;5(3):521-7 - PubMed
  39. J Chromatogr A. 2009 Oct 23;1216(43):7258-67 - PubMed
  40. Eur J Nutr. 2011 Aug;50(5):313-22 - PubMed
  41. Am J Clin Nutr. 2012 Sep;96(3):584-90 - PubMed
  42. Br J Nutr. 2014 Feb;111(4):653-61 - PubMed
  43. J Agric Food Chem. 2009 Feb 11;57(3):1084-92 - PubMed
  44. Pharmacol Res. 2010 Jan;61(1):5-13 - PubMed
  45. Br J Clin Pharmacol. 2013 Mar;75(3):588-602 - PubMed
  46. Hypertension. 2012 Sep;60(3):827-32 - PubMed
  47. J Nutr. 2015 Oct;145(10 ):2325-32 - PubMed
  48. Expert Opin Ther Targets. 2012 Mar;16(3):269-97 - PubMed
  49. J Hypertens. 2015 Feb;33(2):294-303 - PubMed
  50. Eur J Nutr. 2014 Feb;53(1):149-58 - PubMed
  51. Eur J Clin Nutr. 1999 Jan;53(1):22-6 - PubMed
  52. Eur Heart J. 2010 Nov;31(21):2583-92 - PubMed
  53. Nutrients. 2014 Sep 03;6(9):3451-9 - PubMed

Publication Types