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Kim J, Nakamura T, Yamamoto Y. A momentary biomarker for depressive mood. In Silico Pharmacol. 2016;4(1):4doi: 10.1186/s40203-016-0017-6.
Kim, J., Nakamura, T., & Yamamoto, Y. (2016). A momentary biomarker for depressive mood. In silico pharmacology, 4(1), 4. https://doi.org/10.1186/s40203-016-0017-6
Kim, Jinhyuk, et al. "A momentary biomarker for depressive mood." In silico pharmacology vol. 4,1 (2016): 4. doi: https://doi.org/10.1186/s40203-016-0017-6
Kim J, Nakamura T, Yamamoto Y. A momentary biomarker for depressive mood. In Silico Pharmacol. 2016 Dec;4(1):4. doi: 10.1186/s40203-016-0017-6. Epub 2016 Mar 16. PMID: 26979449; PMCID: PMC4792818.
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In Silico Pharmacol. 2016 Dec;4(1):4. doi: 10.1186/s40203-016-0017-6. Epub 2016 Mar 16.

A momentary biomarker for depressive mood.

In silico pharmacology

Jinhyuk Kim, Toru Nakamura, Yoshiharu Yamamoto

Affiliations

  1. Graduate School of Education, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  2. Department of Psychosomatic Research, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8553, Japan.
  3. Graduate School of Education, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. [email protected].

PMID: 26979449 PMCID: PMC4792818 DOI: 10.1186/s40203-016-0017-6

Abstract

Many biomarkers from genetic, neuroimaging, and biological/biochemical measures have been recently developed in order to make a shift toward the objective evaluation of psychiatric disorders. However, they have so far been less successful in capturing dynamical changes or transitions in pathological states, such as those occurring during the course of clinical treatments or pathogenic processes of disorders. A momentary biomarker is now required for objective monitoring of such dynamical changes. The development of ecological momentary assessment (EMA) allows the assessment of dynamical aspects of diurnal/daily clinical conditions and subjective symptoms. Furthermore, a variety of validation studies on momentary symptoms assessed by EMA using behavioral/physiological/biochemical measures have demonstrated the possibility of evaluating momentary symptoms from such external objective measures. In this review, we introduce physical activity as a candidate biobehavioral biomarker for psychiatric disorders. We also mention its potential as a momentary biomarker for depressive mood. Finally, we address the continuous monitoring of the pathogenic processes and pathological states of depressive disorders based on physical activity, as well as its application in pharmacological animal studies.

Keywords: Depressive mood; Ecological momentary assessment; Major depressive disorders; Physical activity; Psychobehavioral biomarker

References

  1. Health Psychol. 1998 Jan;17(1):6-16 - PubMed
  2. Psychiatry Res. 2013 Dec 30;214(3):277-84 - PubMed
  3. Neuroscience. 2016 May 3;321:77-98 - PubMed
  4. Nat Neurosci. 2010 Oct;13(10):1161-9 - PubMed
  5. Br J Health Psychol. 2013 Feb;18(1):155-67 - PubMed
  6. PLoS One. 2013 Sep 13;8(9):e74979 - PubMed
  7. Psychol Assess. 2009 Dec;21(4):457-62 - PubMed
  8. Psychol Addict Behav. 2005 Jun;19(2):140-7 - PubMed
  9. IEEE J Biomed Health Inform. 2015 Jul;19(4):1347-55 - PubMed
  10. Phys Rev Lett. 2007 Sep 28;99(13):138103 - PubMed
  11. Biol Psychiatry. 2015 Aug 15;78(4):231-9 - PubMed
  12. PLoS One. 2008 Apr 30;3(4):e2050 - PubMed
  13. Bipolar Disord. 2009 Dec;11(8):807-14 - PubMed
  14. Physiol Behav. 2015 Jan;138:200-7 - PubMed
  15. PLoS One. 2012;7(6):e38761 - PubMed
  16. Health Psychol. 2012 Mar;31(2):135-44 - PubMed
  17. IEEE Trans Biomed Eng. 2010 Dec;57(12):2850-60 - PubMed
  18. Drug Alcohol Depend. 2007 Dec 1;91(2-3):159-68 - PubMed
  19. Drug Alcohol Depend. 2011 Sep 1;117(2-3):118-25 - PubMed
  20. Br J Psychiatry. 2009 Sep;195(3):194-201 - PubMed
  21. J Affect Disord. 2014 Oct;168:387-98 - PubMed
  22. Behav Res Ther. 2009 Mar;47(3):181-8 - PubMed
  23. Biol Psychol. 2011 Jan;86(1):50-6 - PubMed
  24. World Psychiatry. 2014 Oct;13(3):211-23 - PubMed
  25. J Affect Disord. 2012 Dec 10;141(2-3):457-63 - PubMed
  26. Mol Psychiatry. 2013 Jan;18(1):67-78 - PubMed
  27. Breast Cancer Res Treat. 1995;36(2):227-36 - PubMed
  28. Health Psychol. 2012 Nov;31(6):763-6 - PubMed
  29. J Psychiatry Neurosci. 2013 Mar;38(2):75-7 - PubMed
  30. Psychoneuroendocrinology. 1998 May;23(4):353-70 - PubMed
  31. Annu Rev Clin Psychol. 2013;9:151-76 - PubMed
  32. Neurobiol Dis. 2012 Jul;47(1):13-9 - PubMed
  33. Nature. 2009 Jul 9;460(7252):202-7 - PubMed
  34. Psychosom Med. 2012 May;74(4):327-37 - PubMed
  35. Psychoneuroendocrinology. 2007 Jan;32(1):56-64 - PubMed
  36. J Affect Disord. 2013 Feb 15;145(1):21-8 - PubMed
  37. Psychosom Med. 1996 Sep-Oct;58(5):447-58 - PubMed
  38. Neurosci Biobehav Rev. 2015 Oct;57:328-49 - PubMed
  39. Biol Psychiatry. 2011 Oct 1;70(7):619-25 - PubMed
  40. Menopause. 2009 Jul-Aug;16(4):671-9 - PubMed
  41. Hum Psychopharmacol. 2007 Jan;22(1):1-9 - PubMed
  42. Transl Psychiatry. 2014 Nov 11;4:e479 - PubMed
  43. BMC Res Notes. 2010 May 27;3:149 - PubMed
  44. Ann Behav Med. 2009 Dec;38(3):249-55 - PubMed
  45. Arch Gen Psychiatry. 1997 Feb;54(2):124-30 - PubMed
  46. J Abnorm Psychol. 2011 Aug;120(3):572-84 - PubMed
  47. Annu Rev Clin Psychol. 2008;4:1-32 - PubMed
  48. PLoS One. 2012;7(8):e43539 - PubMed
  49. J Affect Disord. 2013 Feb 20;145(2):260-3 - PubMed
  50. Biol Psychiatry. 2016 Jan 1;79(1):53-61 - PubMed
  51. J Psychiatry Neurosci. 2006 Jan;31(1):13-20 - PubMed
  52. J Abnorm Psychol. 2013 Aug;122(3):672-83 - PubMed
  53. Psychosom Med. 2008 Sep;70(7):819-28 - PubMed
  54. PLoS One. 2013;8(1):e48814 - PubMed
  55. J Pers. 2005 Dec;73(6):1749-74 - PubMed
  56. Health Psychol. 1998 Jan;17(1):17-29 - PubMed
  57. Curr Pharm Des. 2012;18(36):5976-89 - PubMed
  58. Biol Psychiatry. 2016 Jan 1;79(1):62-70 - PubMed
  59. J Affect Disord. 2003 Sep;76(1-3):23-30 - PubMed
  60. Neuroimage. 2014 Jan 1;84:299-306 - PubMed
  61. J Affect Disord. 2013 Mar 20;146(1):112-9 - PubMed

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