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Spadaccio C, Nappi F, De Marco F, et al. Preliminary In Vivo Evaluation of a Hybrid Armored Vascular Graft Combining Electrospinning and Additive Manufacturing Techniques. Drug Target Insights. 2016;10:1-7doi: 10.4137/DTI.S35202.
Spadaccio, C., Nappi, F., De Marco, F., Sedati, P., Sutherland, F. W., Chello, M., Trombetta, M., & Rainer, A. (2016). Preliminary In Vivo Evaluation of a Hybrid Armored Vascular Graft Combining Electrospinning and Additive Manufacturing Techniques. Drug target insights, 101-7. https://doi.org/10.4137/DTI.S35202
Spadaccio, Cristiano, et al. "Preliminary In Vivo Evaluation of a Hybrid Armored Vascular Graft Combining Electrospinning and Additive Manufacturing Techniques." Drug target insights vol. 10 (2016): 1-7. doi: https://doi.org/10.4137/DTI.S35202
Spadaccio C, Nappi F, De Marco F, Sedati P, Sutherland FW, Chello M, Trombetta M, Rainer A. Preliminary In Vivo Evaluation of a Hybrid Armored Vascular Graft Combining Electrospinning and Additive Manufacturing Techniques. Drug Target Insights. 2016 Feb 28;10:1-7. doi: 10.4137/DTI.S35202. eCollection 2016. PMID: 26949333; PMCID: PMC4772909.
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Drug Target Insights. 2016 Feb 28;10:1-7. doi: 10.4137/DTI.S35202. eCollection 2016.

Preliminary In Vivo Evaluation of a Hybrid Armored Vascular Graft Combining Electrospinning and Additive Manufacturing Techniques.

Drug target insights

Cristiano Spadaccio, Francesco Nappi, Federico De Marco, Pietro Sedati, Fraser W H Sutherland, Massimo Chello, Marcella Trombetta, Alberto Rainer

Affiliations

  1. Department of Cardiothoracic Surgery, Golden Jubilee National Hospital, Clydebank, Dunbartonshire, UK.
  2. Cardiac Surgery, Centre Cardiologique du Nord de Saint-Denis, Paris, France.
  3. Laboratory of Virology, The Regina Elena National Cancer Institute, Rome, Italy.
  4. Unit of Imaging and Diagnostics, Università Campus Bio-Medico di Roma, Rome, Italy.
  5. Unit of Cardiac Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
  6. Tissue Engineering Laboratory, Università Campus Bio-Medico di Roma, Rome, Italy.

PMID: 26949333 PMCID: PMC4772909 DOI: 10.4137/DTI.S35202

Abstract

In this study, we tested in vivo effectiveness of a previously developed poly-l-lactide/poly-ε-caprolactone armored vascular graft releasing heparin. This bioprosthesis was designed in order to overcome the main drawbacks of tissue-engineered vascular grafts, mainly concerning poor mechanical properties, thrombogenicity, and endothelialization. The bioprosthesis was successfully implanted in an aortic vascular reconstruction model in rabbits. All grafts implanted were patent at four weeks postoperatively and have been adequately populated by endogenous cells without signs of thrombosis or structural failure and with no need of antiplatelet therapy. The results of this preliminary study might warrant for further larger controlled in vivo studies to further confirm these findings.

Keywords: additive manufacturing; computer-aided tissue engineering; drug release; electrospinning; heparin; vascular graft

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