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Moriyasu K, Ichinose T, Nakahata A, et al. The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem. Int J Pept. 2016;2016:6020786doi: 10.1155/2016/6020786.
Moriyasu, K., Ichinose, T., Nakahata, A., Tanaka, M., Matsui, T., & Furuya, S. (2016). The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem. International journal of peptides, 20166020786. https://doi.org/10.1155/2016/6020786
Moriyasu, Kazuki, et al. "The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem." International journal of peptides vol. 2016 (2016): 6020786. doi: https://doi.org/10.1155/2016/6020786
Moriyasu K, Ichinose T, Nakahata A, Tanaka M, Matsui T, Furuya S. The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem. Int J Pept. 2016;2016:6020786. doi: 10.1155/2016/6020786. Epub 2016 Feb 11. PMID: 26981137; PMCID: PMC4766323.
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Int J Pept. 2016;2016:6020786. doi: 10.1155/2016/6020786. Epub 2016 Feb 11.

The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem.

International journal of peptides

Kazuki Moriyasu, Takashi Ichinose, Akane Nakahata, Mitsuru Tanaka, Toshiro Matsui, Shigeki Furuya

Affiliations

  1. Laboratory of Functional Genomics and Metabolism, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
  2. Laboratory of Food Analysis, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
  3. Laboratory of Functional Genomics and Metabolism, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan; Innovative Bio-Architecture Center, Kyushu University, Fukuoka 812-8581, Japan.

PMID: 26981137 PMCID: PMC4766323 DOI: 10.1155/2016/6020786

Abstract

Catecholamine synthesis and transmission in the brain are influenced by the availability of Tyr in the body. In this study, we compared the effects of oral administration of Tyr-containing dipeptides Ile-Tyr, Ser-Tyr, and Tyr-Pro with Tyr alone on catecholamine metabolism in the mouse brainstem. Among these dipeptides, Ile-Tyr administration led to increases in dopamine, the dopamine metabolites homovanillic acid, and 3,4-dihydroxyphenylacetic acid, compared to administration of Ser-Tyr, Tyr-Pro, or Tyr alone. In comparison, administration of Ser-Tyr induced significantly increasing noradrenaline turnover, while Tyr-Pro administration suppressed dopamine turnover. Therefore, oral administration of Ile-Tyr, Ser-Tyr, and Tyr-Pro differentially affected metabolism of dopamine and noradrenaline. These observations strongly suggest that Tyr-containing dipeptides exert distinct effects on catecholamine metabolism in the brainstem when ingested orally.

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