Display options
Cite
Mallick S, Gandhi AK, Benson R, et al. Outcomes of adult medulloblastoma treated with a multimodality approach: A tertiary cancer center experience. South Asian J Cancer. 2015;4(4):174-8doi: 10.4103/2278-330X.175954.
Mallick, S., Gandhi, A. K., Benson, R., Sharma, D. N., Haresh, K. P., Gupta, S., Julka, P. K., & Rath, G. K. (2015). Outcomes of adult medulloblastoma treated with a multimodality approach: A tertiary cancer center experience. South Asian journal of cancer, 4(4), 174-8. https://doi.org/10.4103/2278-330X.175954
Mallick, Supriya, et al. "Outcomes of adult medulloblastoma treated with a multimodality approach: A tertiary cancer center experience." South Asian journal of cancer vol. 4,4 (2015): 174-8. doi: https://doi.org/10.4103/2278-330X.175954
Mallick S, Gandhi AK, Benson R, Sharma DN, Haresh KP, Gupta S, Julka PK, Rath GK. Outcomes of adult medulloblastoma treated with a multimodality approach: A tertiary cancer center experience. South Asian J Cancer. 2015 Oct-Dec;4(4):174-8. doi: 10.4103/2278-330X.175954. PMID: 26981508; PMCID: PMC4772394.
Copy Download .nbib Format: NLM
Share it on

South Asian J Cancer. 2015 Oct-Dec;4(4):174-8. doi: 10.4103/2278-330X.175954.

Outcomes of adult medulloblastoma treated with a multimodality approach: A tertiary cancer center experience.

South Asian journal of cancer

Supriya Mallick, Ajeet Kumar Gandhi, Rony Benson, Daya Nand Sharma, Kunhi Parambath Haresh, Subhash Gupta, Pramod Kumar Julka, Goura Kisor Rath

Affiliations

  1. Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.

PMID: 26981508 PMCID: PMC4772394 DOI: 10.4103/2278-330X.175954

Abstract

OBJECTIVES: Adult medulloblastoma (AMB) is a rare central nervous system tumor. We aimed to analyze the treatment outcomes of AMB treated at our institute with surgery followed by craniospinal irradiation (CSI) and adjuvant chemotherapy.

METHODS: We retrospectively evaluated the treatment charts of 31 patients of AMB treated from 2003-2011. The patient demography, treatment details and survival data were collected in a predesigned proforma. Kaplan Meier method was used to analyze disease free survival (DFS) and the impact of prognostic factors was determined by univariate analysis (log rank test).

RESULTS: Male: Female ratio was 21:10. Cerebrospinal fluid dissemination was noted in 16% cases. CSI (36 Gray at 1.8 Gray/fraction to entire neuraxis and 20 Gray at 2 Gray/fraction boost to posterior fossa) was used in all cases. 26 patients received adjuvant chemotherapy (carboplatin plus etoposide). Median follows up was 26.85 months (9.47-119.73 months). The estimated 3 and 5 years DFS was found to be 84.9% and 50.7% respectively. On univariate analysis, tumor located laterally had a trend towards better DFS (HR 3.04; 95%CI 0.722 to 12.812; P = 0.07) compared to midline tumors. Other factors like adjuvant chemotherapy, age, gender, surgical extent had no statistically significant impact on survival.

CONCLUSION: The results of our study (largest series from India) show that the regimen of surgery, adjuvant CSI and chemotherapy is feasible and confers descent survival. AMB patients should be treated with a multimodality approach in a tertiary care centre.

Keywords: Adult medulloblastoma; chemotherapy; radiation

References

  1. Int J Radiat Oncol Biol Phys. 1998 Aug 1;42(1):147-54 - PubMed
  2. J Clin Oncol. 2011 Jul 1;29(19):2717-23 - PubMed
  3. Int J Radiat Oncol Biol Phys. 1990 Apr;18(4):763-72 - PubMed
  4. JAMA. 1998 May 13;279(18):1474-6 - PubMed
  5. J Neurosurg Sci. 1991 Jan-Mar;35(1):23-30 - PubMed
  6. Int J Radiat Oncol Biol Phys. 2003 Nov 1;57(3):755-61 - PubMed
  7. Radiother Oncol. 1993 Dec;29(3):301-7 - PubMed
  8. J Neurooncol. 2012 Feb;106(3):595-600 - PubMed
  9. Neurosurgery. 2000 Sep;47(3):623-31; discussion 631-2 - PubMed
  10. J Clin Oncol. 1990 Jul;8(7):1277-80 - PubMed
  11. J Neurosurg. 1981 Jul;55(1):43-51 - PubMed
  12. Neuro Oncol. 2001 Jan;3(1):29-34 - PubMed
  13. Cancer. 1992 Apr 15;69(8):2143-8 - PubMed
  14. J Clin Neurosci. 2008 Feb;15(2):122-6 - PubMed
  15. J Clin Oncol. 2006 Sep 1;24(25):4202-8 - PubMed
  16. Acta Neuropathol. 2007 Aug;114(2):97-109 - PubMed
  17. Int J Radiat Oncol Biol Phys. 2007 Jun 1;68(2):433-40 - PubMed
  18. Crit Rev Oncol Hematol. 2009 Aug;71(2):165-79 - PubMed
  19. Int J Radiat Oncol Biol Phys. 2006 Feb 1;64(2):402-7 - PubMed
  20. J Neurosurg. 1989 Apr;70(4):536-44 - PubMed
  21. Eur J Cancer. 2005 Jun;41(9):1304-10 - PubMed
  22. J Clin Oncol. 2000 Aug;18(16):3004-11 - PubMed
  23. Neuro Oncol. 2001 Jul;3(3):167-73 - PubMed
  24. Radiology. 1969 Dec;93(6):1351-9 - PubMed
  25. J Neurooncol. 2013 Aug;114(1):141-8 - PubMed

Publication Types