Display options
Cite
Gharpure SJ, Nanda SK. Stereoselective synthesis of thiazino[4,3-a]indoles using the thia-Pictet-Spengler reaction of indoles bearing N-tethered thiols and vinylogous thiocarbonates. Org Biomol Chem. 2016;14(24):5586-90doi: 10.1039/c6ob00501b.
Gharpure, S. J., & Nanda, S. K. (2016). Stereoselective synthesis of thiazino[4,3-a]indoles using the thia-Pictet-Spengler reaction of indoles bearing N-tethered thiols and vinylogous thiocarbonates. Organic & biomolecular chemistry, 14(24), 5586-90. https://doi.org/10.1039/c6ob00501b
Gharpure, Santosh J, and Nanda, Santosh K. "Stereoselective synthesis of thiazino[4,3-a]indoles using the thia-Pictet-Spengler reaction of indoles bearing N-tethered thiols and vinylogous thiocarbonates." Organic & biomolecular chemistry vol. 14,24 (2016): 5586-90. doi: https://doi.org/10.1039/c6ob00501b
Gharpure SJ, Nanda SK. Stereoselective synthesis of thiazino[4,3-a]indoles using the thia-Pictet-Spengler reaction of indoles bearing N-tethered thiols and vinylogous thiocarbonates. Org Biomol Chem. 2016 Jun 28;14(24):5586-90. doi: 10.1039/c6ob00501b. Epub 2016 Mar 24. PMID: 27011230.
Copy Download .nbib Format: NLM
Share it on

Org Biomol Chem. 2016 Jun 28;14(24):5586-90. doi: 10.1039/c6ob00501b. Epub 2016 Mar 24.

Stereoselective synthesis of thiazino[4,3-a]indoles using the thia-Pictet-Spengler reaction of indoles bearing N-tethered thiols and vinylogous thiocarbonates.

Organic & biomolecular chemistry

Santosh J Gharpure, Santosh K Nanda

Affiliations

  1. Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai - 400076, India. [email protected].

PMID: 27011230 DOI: 10.1039/c6ob00501b

Abstract

An inter- as well as intra-molecular thia-Pictet-Spengler cyclization of N-tethered thiols and vinylogous thiocarbonates is described for the stereoselective synthesis of N-fused thiazinoindole derivatives. The strategy is extended to one-pot, sequential Friedel-Crafts alkylation - Pictet-Spengler cyclization and the synthesis of thiazino-oxepino-indole.

Publication Types