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Mory DB, Gabbay MA, Rocco ER, et al. High frequency of vitamin D receptor gene polymorphism FokI in Brazilian Type 1 diabetes mellitus patients with clinical autoimmune thyroid disease. Diabetol Metab Syndr. 2016;8:29doi: 10.1186/s13098-016-0145-5.
Mory, D. B., Gabbay, M. A., Rocco, E. R., Kasamatsu, T., Crispim, F., Miranda, W. L., & Dib, S. A. (2016). High frequency of vitamin D receptor gene polymorphism FokI in Brazilian Type 1 diabetes mellitus patients with clinical autoimmune thyroid disease. Diabetology & metabolic syndrome, 829. https://doi.org/10.1186/s13098-016-0145-5
Mory, Denise Barreto, et al. "High frequency of vitamin D receptor gene polymorphism FokI in Brazilian Type 1 diabetes mellitus patients with clinical autoimmune thyroid disease." Diabetology & metabolic syndrome vol. 8 (2016): 29. doi: https://doi.org/10.1186/s13098-016-0145-5
Mory DB, Gabbay MA, Rocco ER, Kasamatsu T, Crispim F, Miranda WL, Dib SA. High frequency of vitamin D receptor gene polymorphism FokI in Brazilian Type 1 diabetes mellitus patients with clinical autoimmune thyroid disease. Diabetol Metab Syndr. 2016 Mar 22;8:29. doi: 10.1186/s13098-016-0145-5. eCollection 2016. PMID: 27011770; PMCID: PMC4804530.
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Diabetol Metab Syndr. 2016 Mar 22;8:29. doi: 10.1186/s13098-016-0145-5. eCollection 2016.

High frequency of vitamin D receptor gene polymorphism FokI in Brazilian Type 1 diabetes mellitus patients with clinical autoimmune thyroid disease.

Diabetology & metabolic syndrome

Denise Barreto Mory, Monica Andrade Lima Gabbay, Eloá R Rocco, Teresa Kasamatsu, Felipe Crispim, Walquíria Lopes Miranda, Sérgio Atala Dib

Affiliations

  1. Endocrinology Division, São Paulo Federal University, Rua Botucatu, 740-Vila Clementino, São Paulo, SP CEP 04034-970 Brazil.

PMID: 27011770 PMCID: PMC4804530 DOI: 10.1186/s13098-016-0145-5

Abstract

BACKGROUND: Polymorphisms of vitamin D receptor (VDR) gene have been studied as genetic markers of type 1 diabetes mellitus (T1DM) and some studies have reported associations with autoimmune thyroid disease. The aim of this study was to evaluate the relationship between VDR FokI polymorphism (rs10735810), thyroid autoimmunity and thyroid dysfunction (TD) in Brazilian T1DM.

METHODS: One-hundred-eighty T1DM patients were evaluated for age, duration of diabetes (DDM), positivity to TPO Antibody (TPOA), GAD Antibody (GADA), IA2 Antibody (IA2A) and fasting serum C-peptide (FCP) according to diagnosis of TD. PCR-RFLP analyses were carried out for VDR polymorphism FokI.

RESULTS: TPOA positivity (80.0 vs. 25.0 %, p < 0.001) and GADA positivity (56.0 vs. 30.3 %, p = 0.01) were higher in T1DM patients with TD with the same age and DDM than the group without TD, with no difference of FCP and IA2A positivity. We observed higher prevalence of VDR FokI in T1DM with TD (ff and Ff 73.9 % with TD vs. 52.7 % without TD, p = 0.05). Positivity to TPOA and presence of FokI polymorphism were significantly associated with the concurrence of TD in T1DM patients (OR 18.1; CI 3.7-87.0; p < 0.001).

CONCLUSIONS: The VDR FokI polymorphism (rs10735810) was associated to persistence of GADA, TPOA positivity and TD in Brazilian T1DM. Positivity to TPOA and VDR polymorphism FokI were strongly associated with concurrence of T1D and TD. These data collaborate to understanding the joint susceptibility genes for TD in T1DM.

Keywords: Autoimmune thyroid disease; Type 1 diabetes; Vitamin D receptor gene polymorphism

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