Display options
Share it on

World J Transplant. 2016 Mar 24;6(1):174-82. doi: 10.5500/wjt.v6.i1.174.

Imaging-based diagnosis of acute renal allograft rejection.

World journal of transplantation

Gerold Thölking, Katharina Schuette-Nuetgen, Dominik Kentrup, Helga Pawelski, Stefan Reuter

Affiliations

  1. Gerold Thölking, Katharina Schuette-Nuetgen, Dominik Kentrup, Helga Pawelski, Stefan Reuter, Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, 48149 Münster, Germany.

PMID: 27011915 PMCID: PMC4801793 DOI: 10.5500/wjt.v6.i1.174

Abstract

Kidney transplantation is the best available treatment for patients with end stage renal disease. Despite the introduction of effective immunosuppressant drugs, episodes of acute allograft rejection still endanger graft survival. Since efficient treatment of acute rejection is available, rapid diagnosis of this reversible graft injury is essential. For diagnosis of rejection, invasive core needle biopsy of the graft is the "gold-standard". However, biopsy carries the risk of significant graft injury and is not immediately feasible in patients taking anticoagulants. Therefore, a non-invasive tool assessing the whole organ for specific and fast detection of acute allograft rejection is desirable. We herein review current imaging-based state of the art approaches for non-invasive diagnostics of acute renal transplant rejection. We especially focus on new positron emission tomography-based as well as targeted ultrasound-based methods.

Keywords: Acute allograft rejection; Imaging; Kidney transplantation; Magnetic resonance imaging; Positron emission tomography; Renal; Single photon emission computed tomography; Ultrasound

References

  1. PLoS One. 2011;6(10):e25857 - PubMed
  2. Ren Fail. 2015 Apr;37(3):417-23 - PubMed
  3. J Magn Reson Imaging. 2012 May;35(5):1133-8 - PubMed
  4. J Nephrol. 1999 Mar-Apr;12(2):100-3 - PubMed
  5. J Nucl Med. 2015 May;56(5):778-83 - PubMed
  6. J Nucl Med. 2010 Oct;51(10 ):1644-52 - PubMed
  7. N Engl J Med. 2003 Jul 10;349(2):115-24 - PubMed
  8. Eur Radiol. 2015 Oct;25(10):3009-16 - PubMed
  9. Clin Nucl Med. 2015 Jan;40(1):e27-33 - PubMed
  10. Br J Radiol. 2012 Jun;85(1014):e206-11 - PubMed
  11. EJNMMI Res. 2015 Jan 28;5:2 - PubMed
  12. Transplantation. 1999 Aug 27;68(4):563-71 - PubMed
  13. Nucl Med Biol. 2015 Feb;42(2):198-204 - PubMed
  14. Eur Radiol. 2007 Nov;17(11):2898-907 - PubMed
  15. BMC Nephrol. 2014 Oct 01;15:158 - PubMed
  16. Ultraschall Med. 2016 Feb;37(1):82-91 - PubMed
  17. Clin Hemorheol Microcirc. 2011;49(1-4):527-35 - PubMed
  18. Br J Psychiatry. 2015 Feb;206(2):145-52 - PubMed
  19. Nucl Med Biol. 2015 Jan;42(1):46-52 - PubMed
  20. Contrast Media Mol Imaging. 2012 Jan-Feb;7(1):1-6 - PubMed
  21. Clin Nucl Med. 1994 Sep;19(9):782-4 - PubMed
  22. Transplantation. 2015 Mar;99(3):636-41 - PubMed
  23. J Nucl Med. 2013 Jul;54(7):1147-53 - PubMed
  24. PLoS One. 2009;4(4):e5296 - PubMed
  25. Nephrourol Mon. 2015 Jan 20;7(1):e24439 - PubMed
  26. Transplant Proc. 2004 Dec;36(10 ):2997-3001 - PubMed
  27. Biomed Res Int. 2015;2015:914692 - PubMed
  28. Am J Transplant. 2016 Jan;16(1):310-6 - PubMed
  29. Medicine (Baltimore). 2014 Sep;93(11):e67 - PubMed
  30. J Nucl Med. 1976 Mar;17(3):175-80 - PubMed
  31. Eur J Radiol. 2012 May;81(5):838-45 - PubMed
  32. Semin Nucl Med. 1999 Apr;29(2):175-88 - PubMed
  33. Am J Transplant. 2015 Sep;15(9):2483-90 - PubMed
  34. Nucl Med Commun. 2002 Aug;23 (8):721-5 - PubMed
  35. Nucl Med Biol. 2015 Mar;42(3):256-62 - PubMed
  36. Nanomedicine. 2012 Nov;8(8):1345-54 - PubMed
  37. Semin Nucl Med. 1994 Apr;24(2):92-109 - PubMed
  38. Recent Results Cancer Res. 2013;187:65-105 - PubMed
  39. J Nucl Med. 1978 Oct;19(10):1154-61 - PubMed
  40. Clin Nucl Med. 2015 Apr;40(4):309-13 - PubMed
  41. Chem Rev. 2010 May 12;110(5):3112-45 - PubMed
  42. Semin Nucl Med. 2013 Mar;43(2):114-28 - PubMed
  43. Dalton Trans. 2015 Mar 21;44(11):4986-93 - PubMed
  44. Nucl Med Biol. 2009 Jul;36(5):545-9 - PubMed
  45. Magn Reson Imaging. 2011 Jan;29(1):74-82 - PubMed
  46. J Nucl Med. 2002 May;43(5):584-8 - PubMed
  47. Adv Chronic Kidney Dis. 2013 Nov;20(6):488-99 - PubMed
  48. Curr Pharm Biotechnol. 2010 Sep 1;11(6):545-54 - PubMed
  49. J Nucl Med. 2011 Nov;52(11):1713-20 - PubMed
  50. Chem Soc Rev. 2011 Jan;40(1):149-62 - PubMed
  51. Bioconjug Chem. 2015 May 20;26(5):839-49 - PubMed
  52. Transplantation. 2009 Dec 27;88(12):1341-8 - PubMed
  53. Eur J Nucl Med Mol Imaging. 2008 Dec;35(12 ):2267-74 - PubMed
  54. Eur Radiol. 2010 Jun;20(6):1485-91 - PubMed
  55. AJR Am J Roentgenol. 2012 May;198(5):1108-14 - PubMed
  56. N Engl J Med. 1999 Dec 2;341(23):1725-30 - PubMed
  57. Magn Reson Imaging. 2010 Jan;28(1):56-64 - PubMed
  58. Pediatr Transplant. 2007 Nov;11(7):771-6 - PubMed
  59. Acad Radiol. 2009 Sep;16(9):1077-85 - PubMed
  60. J Nucl Med. 1976 Jun;17(6):480-7 - PubMed
  61. Radiology. 2011 Sep;260(3):781-9 - PubMed
  62. J Am Soc Nephrol. 2015 Nov;26(11):2840-51 - PubMed
  63. Transplant Proc. 2009 Mar;41(2):641-4 - PubMed
  64. Am J Transplant. 2013 Oct;13(10 ):2540-9 - PubMed
  65. Radiology. 2013 Jan;266(1):218-25 - PubMed
  66. Nephrol Dial Transplant. 2012 Oct;27(10 ):3958-63 - PubMed
  67. Semin Nucl Med. 2013 Nov;43(6):412-9 - PubMed
  68. Br J Radiol. 2006 Aug;79(944):688-701 - PubMed
  69. J Nucl Med. 2010 Dec;51(12 ):1937-49 - PubMed
  70. Clin Nucl Med. 2009 Dec;34(12):862-8 - PubMed
  71. Cancers (Basel). 2014 Sep 29;6(4):1821-89 - PubMed
  72. Mol Imaging Biol. 2015 Oct;17 (5):671-9 - PubMed
  73. Semin Nucl Med. 2009 May;39(3):156-73 - PubMed
  74. AJNR Am J Neuroradiol. 2015 Feb;36(2):229-35 - PubMed
  75. Nucl Med Biol. 1998 May;25(4):317-22 - PubMed
  76. N Engl J Med. 2013 Nov 7;369(19):1797-806 - PubMed
  77. Clin Radiol. 2014 Jul;69(7):661-8 - PubMed
  78. Radiology. 2010 Sep;256(3):847-54 - PubMed
  79. J Magn Reson Imaging. 2008 Oct;28(4):805-22 - PubMed
  80. Kidney Int. 2014 Apr;85(4):768-78 - PubMed
  81. Lancet. 1986 Oct 25;2(8513):946-9 - PubMed
  82. Transplant Proc. 2004 Nov;36(9):2664-7 - PubMed

Publication Types