Oxf Med Case Reports. 2016 Apr 07;2016(4):55-8. doi: 10.1093/omcr/omw014. eCollection 2016 Apr.

A case of Takotsubo cardiomyopathy after chemotherapy.

Oxford medical case reports

Tamir Malley, Edmund Watson

PMID: 27066260 PMCID: PMC4823761 DOI: 10.1093/omcr/omw014

Abstract

Here we present the case of a patient with diffuse large B-cell lymphoma who was admitted to hospital for an elective autologous peripheral blood stem cell transplant after cytotoxic treatment with lomustine, cytarabine, cyclophosphomide and etoposide (LACE). On the final day of chemotherapeutic treatment, she developed sudden onset dyspnoea. Electrocardiography confirmed acute antero-lateral T-wave inversion. She went onto have coronary angiography that demonstrated unobstructed coronary arteries. Left ventriculography demonstrated apical ballooning, consistent with Takotsubo (stress) cardiomyopathy. The link between chemotherapy and Takotsubo cardiomyopathy has become increasingly recognized in recent years, although causality remains to be established and the mechanism of action is not yet fully understood.

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Publication Types

• Case Reports