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Vuurman EF, Honig A, Lamers TH, et al. Event-related potentials and white matter lesions in bipolar disorder. Acta Neuropsychiatr. 2002;14(1):11-6doi: 10.1034/j.1601-5215.2002.140102.x.
Vuurman, E. F., Honig, A., Lamers, T. H., Wiersma, J., Krabbendam, L., Hofman, P. A., Nolen, W. A., & Jolles, J. (2002). Event-related potentials and white matter lesions in bipolar disorder. Acta neuropsychiatrica, 14(1), 11-6. https://doi.org/10.1034/j.1601-5215.2002.140102.x
Vuurman, E F P M, et al. "Event-related potentials and white matter lesions in bipolar disorder." Acta neuropsychiatrica vol. 14,1 (2002): 11-6. doi: https://doi.org/10.1034/j.1601-5215.2002.140102.x
Vuurman EF, Honig A, Lamers TH, Wiersma J, Krabbendam L, Hofman PA, Nolen WA, Jolles J. Event-related potentials and white matter lesions in bipolar disorder. Acta Neuropsychiatr. 2002 Feb;14(1):11-6. doi: 10.1034/j.1601-5215.2002.140102.x. PMID: 26983862.
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Acta Neuropsychiatr. 2002 Feb;14(1):11-6. doi: 10.1034/j.1601-5215.2002.140102.x.

Event-related potentials and white matter lesions in bipolar disorder.

Acta neuropsychiatrica

E F P M Vuurman, A Honig, T H Lamers, J Wiersma, L Krabbendam, P A M Hofman, W A Nolen, J Jolles

Affiliations

  1. 1Universiteit Maastricht, Department of Neuropsychology.
  2. 2Academisch Ziekenhuis Maastricht, Department of Psychiatry.
  3. 3Academisch Ziekenhuis Maastricht, Department of Radiology.
  4. 4Academisch Ziekenhuis Utrecht, Department of Psychiatry.

PMID: 26983862 DOI: 10.1034/j.1601-5215.2002.140102.x

Abstract

OBJECTIVES: To investigate neurophysiological parameters which possibly distinguish subtypes I and II of patients with a bipolar disorder, and contrast the findings with observations from a group of schizophrenic patients and a group of healthy controls.

METHODS: Sixty-six volunteers underwent a MRI scan to determine the number and location of white matter lesions (WSL). A electrophysiological registration was made while all volunteers performed a auditory 'oddball' task, and the amplitude of the resulting P300 wave was compared.

RESULTS: Earlier reports of higher numbers of WSL in bipolar disorder were not replicated in this study. Subtypes I and II showed a different P300 amplitude and subtype I resembled the results of the schizophrenia group.

CONCLUSION: Bipolar patients in remission have a functional brain disorder that is expressed by a change in physiological response to external stimuli.

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