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Rao Q, Xia QY, Cheng L, et al. Molecular genetics and immunohistochemistry characterization of uncommon and recently described renal cell carcinomas. Chin J Cancer Res. 2016;28(1):29-49doi: 10.3978/j.issn.1000-9604.2016.01.03.
Rao, Q., Xia, Q. Y., Cheng, L., & Zhou, X. J. (2016). Molecular genetics and immunohistochemistry characterization of uncommon and recently described renal cell carcinomas. Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 28(1), 29-49. https://doi.org/10.3978/j.issn.1000-9604.2016.01.03
Rao, Qiu, et al. "Molecular genetics and immunohistochemistry characterization of uncommon and recently described renal cell carcinomas." Chinese journal of cancer research = Chung-kuo yen cheng yen chiu vol. 28,1 (2016): 29-49. doi: https://doi.org/10.3978/j.issn.1000-9604.2016.01.03
Rao Q, Xia QY, Cheng L, Zhou XJ. Molecular genetics and immunohistochemistry characterization of uncommon and recently described renal cell carcinomas. Chin J Cancer Res. 2016 Feb;28(1):29-49. doi: 10.3978/j.issn.1000-9604.2016.01.03. PMID: 27041925; PMCID: PMC4779753.
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Chin J Cancer Res. 2016 Feb;28(1):29-49. doi: 10.3978/j.issn.1000-9604.2016.01.03.

Molecular genetics and immunohistochemistry characterization of uncommon and recently described renal cell carcinomas.

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu

Qiu Rao, Qiu-Yuan Xia, Liang Cheng, Xiao-Jun Zhou

Affiliations

  1. 1 Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China ; 2 Department of Pathology and Laboratory, Indiana University School of Medicine, Indianapolis, IN, USA.

PMID: 27041925 PMCID: PMC4779753 DOI: 10.3978/j.issn.1000-9604.2016.01.03

Abstract

Renal cell carcinoma (RCC) compromises multiple types and has been emerging dramatically over the recent several decades. Advances and consensus have been achieved targeting common RCCs, such as clear cell carcinoma, papillary RCC and chromophobe RCC. Nevertheless, little is known on the characteristics of several newly-identified RCCs, including clear cell (tubulo) papillary RCC, Xp11 translocation RCC, t(6;11) RCC, succinate dehydrogenase (SDH)-deficient RCC, acquired cystic disease-associated RCC, hereditary leiomyomatosis RCC syndrome-associated RCC, ALK translocation RCC, thyroid-like follicular RCC, tubulocystic RCC and hybrid oncocytic/chromophobe tumors (HOCT). In current review, we will collect available literature of these newly-described RCCs, analyze their clinical pathologic characteristics, discuss their morphologic and immunohistologic features, and finally summarize their molecular and genetic evidences. We expect this review would be beneficial for the understanding of RCCs, and eventually promote clinical management strategies.

Keywords: Renal cell carcinoma (RCC); immunohistochemistry; molecular genetics; renal tumor

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