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Song X, Zhang GM, Ma XC, et al. Comparison of preoperative neutrophil-lymphocyte, lymphocyte-monocyte, and platelet-lymphocyte ratios in patients with upper urinary tract urothelial carcinoma undergoing radical nephroureterectomy. Onco Targets Ther. 2016;9:1399-407doi: 10.2147/OTT.S97520.
Song, X., Zhang, G. M., Ma, X. C., Luo, L., Li, B., Chai, D. Y., & Sun, L. J. (2016). Comparison of preoperative neutrophil-lymphocyte, lymphocyte-monocyte, and platelet-lymphocyte ratios in patients with upper urinary tract urothelial carcinoma undergoing radical nephroureterectomy. OncoTargets and therapy, 91399-407. https://doi.org/10.2147/OTT.S97520
Song, Xin, et al. "Comparison of preoperative neutrophil-lymphocyte, lymphocyte-monocyte, and platelet-lymphocyte ratios in patients with upper urinary tract urothelial carcinoma undergoing radical nephroureterectomy." OncoTargets and therapy vol. 9 (2016): 1399-407. doi: https://doi.org/10.2147/OTT.S97520
Song X, Zhang GM, Ma XC, Luo L, Li B, Chai DY, Sun LJ. Comparison of preoperative neutrophil-lymphocyte, lymphocyte-monocyte, and platelet-lymphocyte ratios in patients with upper urinary tract urothelial carcinoma undergoing radical nephroureterectomy. Onco Targets Ther. 2016 Mar 11;9:1399-407. doi: 10.2147/OTT.S97520. eCollection 2016. PMID: 27042108; PMCID: PMC4795585.
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Onco Targets Ther. 2016 Mar 11;9:1399-407. doi: 10.2147/OTT.S97520. eCollection 2016.

Comparison of preoperative neutrophil-lymphocyte, lymphocyte-monocyte, and platelet-lymphocyte ratios in patients with upper urinary tract urothelial carcinoma undergoing radical nephroureterectomy.

OncoTargets and therapy

Xin Song, Gui-Ming Zhang, Xiao-Cheng Ma, Lei Luo, Bin Li, Dong-Yue Chai, Li-Jiang Sun

Affiliations

  1. Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People's Republic of China.

PMID: 27042108 PMCID: PMC4795585 DOI: 10.2147/OTT.S97520

Abstract

PURPOSE: The aim of this study was to investigate the prognostic value of preoperative neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR) in patients with upper urinary tract urothelial carcinoma (UUTUC).

METHODS: We retrospectively analyzed the clinical data of 140 patients with UUTUC who underwent radical nephroureterectomy from January 2005 to December 2011. We plotted receiver operating characteristic curves of NLR, PLR, and LMR for the diagnosis of tumor recurrence. Survival analysis was performed using the Kaplan-Meier method and log-rank test. Independent risk factor analysis was performed using a Cox proportional hazards regression model.

RESULTS: Receiver operating characteristic curves showed that NLR was superior to PLR and LMR as a predictive factor in patients with UUTUC undergoing radical nephroureterectomy. Univariate analysis revealed that NLR (P<0.001 and P<0.001), PLR (P=0.01 and P<0.001), and LMR (P<0.001 and P<0.001) were significantly associated with disease-free survival and progression-free survival (PFS), respectively. Multivariate analysis identified NLR and LMR as independent prognostic factors for disease-free survival (P=0.035 and P=0.002) and PFS (P=0.005 and P=0.002), respectively.

CONCLUSION: NLR and LMR could be independent predictors of disease-free survival and PFS, and NLR is a superior predictive factor to LMR.

Keywords: lymphocyte–monocyte ratio; neutrophil–lymphocyte ratio; platelet–lymphocyte ratio; prognostic factors

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