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Fuentes AL, Hennessy K, Pascual J, et al. Identification of Plant Extracts that Inhibit the Formation of Diabetes-Linked IAPP Amyloid. J Herb Med. 2016;6(1):37-41doi: 10.1016/j.hermed.2015.11.001.
Fuentes, A. L., Hennessy, K., Pascual, J., Pepe, N., Wang, I., Santiago, A., Chaggan, C., Martinez, J., Rivera, E., Cota, P., Cunha, C., Nogaj, L. A., & Moffet, D. A. (2016). Identification of Plant Extracts that Inhibit the Formation of Diabetes-Linked IAPP Amyloid. Journal of herbal medicine, 6(1), 37-41. https://doi.org/10.1016/j.hermed.2015.11.001
Fuentes, Ana Lucia, et al. "Identification of Plant Extracts that Inhibit the Formation of Diabetes-Linked IAPP Amyloid." Journal of herbal medicine vol. 6,1 (2016): 37-41. doi: https://doi.org/10.1016/j.hermed.2015.11.001
Fuentes AL, Hennessy K, Pascual J, Pepe N, Wang I, Santiago A, Chaggan C, Martinez J, Rivera E, Cota P, Cunha C, Nogaj LA, Moffet DA. Identification of Plant Extracts that Inhibit the Formation of Diabetes-Linked IAPP Amyloid. J Herb Med. 2016 Mar;6(1):37-41. doi: 10.1016/j.hermed.2015.11.001. PMID: 27042401; PMCID: PMC4815265.
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J Herb Med. 2016 Mar;6(1):37-41. doi: 10.1016/j.hermed.2015.11.001.

Identification of Plant Extracts that Inhibit the Formation of Diabetes-Linked IAPP Amyloid.

Journal of herbal medicine

Ana Lucia Fuentes, Kathleen Hennessy, Jacob Pascual, Nicole Pepe, In Wang, Alexander Santiago, Cynthia Chaggan, Jessica Martinez, Evelyn Rivera, Paola Cota, Christina Cunha, Luiza A Nogaj, David A Moffet

Affiliations

  1. Department of Chemistry and Biochemistry, Loyola Marymount University, 1 LMU Drive, Los Angeles, CA 90045.
  2. Department of Biology, Mount Saint Mary's College, 12001 Chalon Drive, Los Angeles, CA 90049.

PMID: 27042401 PMCID: PMC4815265 DOI: 10.1016/j.hermed.2015.11.001

Abstract

The extracts of 27 vegetables, spices and herbs were screened for their functional ability to inhibit the aggregation of islet amyloid polypeptide (IAPP, amylin) into toxic amyloid aggregates. The aggregation of IAPP has been directly linked to the death of pancreatic β-islet cells in type 2 diabetes. Inhibiting the aggregation of IAPP is believed to have the potential to slow, if not prevent entirely, the progression of this disease. As vegetables, spices and herbs are known to possess many different positive health effects, the extracts of 27 plants (abundant within the United States and spanning several plant families) were screened for their ability to inhibit the formation of toxic IAPP aggregates. Their anti-amyloid activities were assessed through (1) thioflavin T binding assays, (2) visualization of amyloid fibers using atomic force microscopy and (3) cell rescue studies. From this research, mint, peppermint, red bell pepper and thyme emerged as possessing the greatest anti-amyloid activity.

Keywords: Amyloid Inhibition; Diabetes; Natural Product Therapeutics

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