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Gujral UP, Mohan V, Pradeepa R, et al. Ethnic Variations in Diabetes and Prediabetes Prevalence and the roles of Insulin Resistance and β-cell Function: The CARRS and NHANES Studies. J Clin Transl Endocrinol. 2016;4:19-27doi: 10.1016/j.jcte.2016.02.004.
Gujral, U. P., Mohan, V., Pradeepa, R., Deepa, M., Anjana, R. M., Mehta, N. K., Gregg, E. W., & Narayan, K. (2016). Ethnic Variations in Diabetes and Prediabetes Prevalence and the roles of Insulin Resistance and β-cell Function: The CARRS and NHANES Studies. Journal of clinical & translational endocrinology, 419-27. https://doi.org/10.1016/j.jcte.2016.02.004
Gujral, U P, et al. "Ethnic Variations in Diabetes and Prediabetes Prevalence and the roles of Insulin Resistance and β-cell Function: The CARRS and NHANES Studies." Journal of clinical & translational endocrinology vol. 4 (2016): 19-27. doi: https://doi.org/10.1016/j.jcte.2016.02.004
Gujral UP, Mohan V, Pradeepa R, Deepa M, Anjana RM, Mehta NK, Gregg EW, Narayan K. Ethnic Variations in Diabetes and Prediabetes Prevalence and the roles of Insulin Resistance and β-cell Function: The CARRS and NHANES Studies. J Clin Transl Endocrinol. 2016 Jun 01;4:19-27. doi: 10.1016/j.jcte.2016.02.004. PMID: 27042403; PMCID: PMC4811044.
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J Clin Transl Endocrinol. 2016 Jun 01;4:19-27. doi: 10.1016/j.jcte.2016.02.004.

Ethnic Variations in Diabetes and Prediabetes Prevalence and the roles of Insulin Resistance and β-cell Function: The CARRS and NHANES Studies.

Journal of clinical & translational endocrinology

U P Gujral, V Mohan, R Pradeepa, M Deepa, R M Anjana, N K Mehta, E W Gregg, Kmv Narayan

Affiliations

  1. Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA; Nutrition and Health Sciences Program, Graduate Division of Biomedical and Biological Sciences, Laney Graduate School, Emory University, 1518 Clifton Road NE, Atlanta, GA 30329, USA.
  2. Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialties Centre, WHO Collaborating Centre for Non-communicable Diseases, Prevention & Control, IDF Centre of Education, Chennai, India.
  3. Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  4. Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  5. Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA; Nutrition and Health Sciences Program, Graduate Division of Biomedical and Biological Sciences, Laney Graduate School, Emory University, 1518 Clifton Road NE, Atlanta, GA 30329, USA; Department of Medicine, School of Medicine, Emory University, Atlanta, GA, USA.

PMID: 27042403 PMCID: PMC4811044 DOI: 10.1016/j.jcte.2016.02.004

Abstract

AIMS: It is unclear how the prevalence of diabetes in Asian Indians in urban India compares to that of race/ethnic groups in the US that may have different underlying susceptibilities. Therefore we examined ethnic variations in the prevalence of type 2 diabetes, iIFG, iIGT, IFG+IGT, and the associated risk factors in Asian Indians in Chennai, India, and Whites, Blacks, and Hispanics in the United States.

METHODS: Cross-sectional analyses, using representative samples of 4,867 Asian Indians aged 20-74 years from Chennai, India in the Centre for Cardiometabolic Risk Reduction in

RESULTS: The age-adjusted prevalence of type 2 diabetes was highest in Asian Indians (men; 29.0, 95% CI: 25.9, 31.0), women; (30.6, 95% CI, 27.5, 33.9)) and lowest in Caucasians (men; 12.2, 95% CI, 10.3, 14.4), women; 9.5 (7.9, 11.5). Asian Indians had the lowest prediabetes prevalence (men; 19.0 (17.2, 20.8); women 27.2, 95% CI, 22.8, 32.1)) and Caucasians had the highest (men; 46.5 (43.5, 49.6), women; 34.4, 95% CI, 31.7, 37.3). However, there were differences in prediabetes prevalence by gender and prediabetes state. The inclusion of HOMA-β in standardized polytomous logistic regression models resulted in a greater odds of diabetes in Blacks and Hispanics compared to Asian Indians.

CONCLUSIONS: The high prevalence of diabetes in Asian Indians may be due to innate susceptibilities for β-cell dysfunction in this high risk population.

Keywords: Asian Indian; Ethnicity; Type 2 Diabetes

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