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Schmid AJ, Dubbert J, Rudov AA, et al. Multi-Shell Hollow Nanogels with Responsive Shell Permeability. Sci Rep. 2016;6:22736doi: 10.1038/srep22736.
Schmid, A. J., Dubbert, J., Rudov, A. A., Pedersen, J. S., Lindner, P., Karg, M., Potemkin, I. I., & Richtering, W. (2016). Multi-Shell Hollow Nanogels with Responsive Shell Permeability. Scientific reports, 622736. https://doi.org/10.1038/srep22736
Schmid, Andreas J, et al. "Multi-Shell Hollow Nanogels with Responsive Shell Permeability." Scientific reports vol. 6 (2016): 22736. doi: https://doi.org/10.1038/srep22736
Schmid AJ, Dubbert J, Rudov AA, Pedersen JS, Lindner P, Karg M, Potemkin II, Richtering W. Multi-Shell Hollow Nanogels with Responsive Shell Permeability. Sci Rep. 2016 Mar 17;6:22736. doi: 10.1038/srep22736. PMID: 26984478; PMCID: PMC4794761.
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Sci Rep. 2016 Mar 17;6:22736. doi: 10.1038/srep22736.

Multi-Shell Hollow Nanogels with Responsive Shell Permeability.

Scientific reports

Andreas J Schmid, Janine Dubbert, Andrey A Rudov, Jan Skov Pedersen, Peter Lindner, Matthias Karg, Igor I Potemkin, Walter Richtering

Affiliations

  1. Institute of Physical Chemistry, RWTH Aachen University, Landoltweg 2, 52056 Aachen, Germany.
  2. Physics Department, Lomonosov Moscow State University, 119991 Moscow, Russian Federation.
  3. DWI-Leibnitz Institute for Interactive Materials e.V., 52056 Aachen, Germany.
  4. Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, 8000 Aarhus, Denmark.
  5. Institut Laue Langevin (ILL), 71 avenue des Martyrs, 38000 Grenoble, France.
  6. Physical Chemistry I, University of Bayreuth, 85440 Bayreuth, Germany.

PMID: 26984478 PMCID: PMC4794761 DOI: 10.1038/srep22736

Abstract

We report on hollow shell-shell nanogels with two polymer shells that have different volume phase transition temperatures. By means of small angle neutron scattering (SANS) employing contrast variation and molecular dynamics (MD) simulations we show that hollow shell-shell nanocontainers are ideal systems for controlled drug delivery: The temperature responsive swelling of the inner shell controls the uptake and release, while the thermoresponsive swelling of the outer shell controls the size of the void and the colloidal stability. At temperatures between 32 °C < T < 42 °C, the hollow nanocontainers provide a significant void, which is even larger than the initial core size of the template, and they possess a high colloidal stability due to the steric stabilization of the swollen outer shell. Computer simulations showed, that temperature induced switching of the permeability of the inner shell allows for the encapsulation in and release of molecules from the cavity.

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