J Clin Diagn Res. 2016 Feb;10(2):BC01-3. doi: 10.7860/JCDR/2016/12754.7163. Epub 2016 Feb 01.
Comparative Study of 5'-Nucleotidase Test in Various Liver Diseases.
Journal of clinical and diagnostic research : JCDR
Mohd Azam Hyder, Marghoob Hasan, Abdelmarouf Mohieldein
Affiliations
Affiliations
- Associate Professor, Department of Biochemistry, College of Medicine, Jouf University , Kingdom of Saudi Arabia; Gandhi Medical College, Hyderabad, India .
- Lecturer, Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University , Buraidah 51452, Kingdom of Saudi Arabia .
- Associate Professor, Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University , Buraidah 51452, Kingdom of Saudi Arabia .
PMID: 27042442
PMCID: PMC4800507 DOI: 10.7860/JCDR/2016/12754.7163
Abstract
INTRODUCTION: The liver regulates many important metabolic functions. The 5'-nucleotidase activity is increased in obstructive jaundice, parenchymal liver disease, and hepatic metastases.
AIM: This study was conducted to assess the serum levels of 5'-nucleotidase on patients with viral hepatitis, alcoholic liver diseases and liver cirrhosis, moreover to make comparison to assess the degree of biliary involvement.
MATERIALS AND METHODS: A total of 60 male subjects (15 healthy controls and 45 case subjects) were enrolled, aged between 30 -50 years, each case group consisted of 15 male age-matched patients suffering with viral hepatitis, alcoholic liver disease (more than 10 years.) and liver cirrhosis. Serum 5'-nucleotidase was analyzed as per the standard laboratory procedure.
RESULTS: The 5'-nucleotidase levels were significantly raised in viral hepatitis, alcoholic liver disease and cirrhosis patients. The levels being 35.2±8.43, 29.87±3.94, and 24.07± 4.33 respectively as compared to healthy control (11±3.42) U/L.
CONCLUSION: Serum 5'-nucleotidase levels showed elevations in mean value of three fold in viral hepatitis, 2.5 folds elevation in alcoholic liver disease and two fold in cirrhosis as compared of healthy control subjects.
Keywords: Alcoholic liver diseases; Biliary obstruction; Cirrhosis; Serum 5’-Nucleotidase; Viral hepatitis
References
- Technol Health Care. 2013;21(5):417-32 - PubMed
- Indian J Clin Biochem. 2004 Jul;19(2):128-31 - PubMed
- Gastroenterol Jpn. 1990 Apr;25(2):199-205 - PubMed
- J Clin Pathol. 1954 Nov;7(4):341-3 - PubMed
- Indian J Clin Biochem. 1999 Jan;14(1):59-90 - PubMed
- Cancer. 1966 Sep;19(9):1281-5 - PubMed
- Clin Chem. 2001 Nov;47(11):2046-8 - PubMed
- Alcohol Res Health. 2003;27(3):247-56 - PubMed
- BMC Med. 2014 Sep 18;12:159 - PubMed
- Pan Afr Med J. 2009 Nov 22;3:17 - PubMed
- Indian J Pediatr. 2007 Jul;74(7):663-71 - PubMed
- Indian J Clin Biochem. 2000 Aug;15(1):48-51 - PubMed
Publication Types