Display options
Cite
Nasiri AA, Ahmadidarrehsima S, Balouchi A, et al. Effect of Heparin on Coagulation Tests: A Comparison of Continuous and Bolus Infusion in Haemodialysis Patients. J Clin Diagn Res. 2016;10(2):OC18-21doi: 10.7860/JCDR/2016/18476.7231.
Nasiri, A. A., Ahmadidarrehsima, S., Balouchi, A., Shahdadi, H., & Moghadam, M. P. (2016). Effect of Heparin on Coagulation Tests: A Comparison of Continuous and Bolus Infusion in Haemodialysis Patients. Journal of clinical and diagnostic research : JCDR, 10(2), OC18-21. https://doi.org/10.7860/JCDR/2016/18476.7231
Nasiri, Ali Akbar, et al. "Effect of Heparin on Coagulation Tests: A Comparison of Continuous and Bolus Infusion in Haemodialysis Patients." Journal of clinical and diagnostic research : JCDR vol. 10,2 (2016): OC18-21. doi: https://doi.org/10.7860/JCDR/2016/18476.7231
Nasiri AA, Ahmadidarrehsima S, Balouchi A, Shahdadi H, Moghadam MP. Effect of Heparin on Coagulation Tests: A Comparison of Continuous and Bolus Infusion in Haemodialysis Patients. J Clin Diagn Res. 2016 Feb;10(2):OC18-21. doi: 10.7860/JCDR/2016/18476.7231. Epub 2016 Feb 01. PMID: 27042496; PMCID: PMC4800562.
Copy Download .nbib Format: NLM
Share it on

J Clin Diagn Res. 2016 Feb;10(2):OC18-21. doi: 10.7860/JCDR/2016/18476.7231. Epub 2016 Feb 01.

Effect of Heparin on Coagulation Tests: A Comparison of Continuous and Bolus Infusion in Haemodialysis Patients.

Journal of clinical and diagnostic research : JCDR

Ali Akbar Nasiri, Sudabeh Ahmadidarrehsima, Abbas Balouchi, Hosein Shahdadi, Mahdiye Poodine Moghadam

Affiliations

  1. Faculty of Medicine School, Department of Anaesthesiology and Pain Medicine, School of Medicine, Zabol University of Medical Science , IR Iran .
  2. MSc Student of Nursing, Department of Medical Surgical, Student Research Committee (SRC), School of Nursing and Midwifery, Zabol University of Medical Sciences (zbmu) , Zabol, IR Iran .
  3. MSc in Nursing, Department of Medical Surgical, School of Nursing and Midwifery, Zabol University of Medical Sciences , Zabol, IR Iran .

PMID: 27042496 PMCID: PMC4800562 DOI: 10.7860/JCDR/2016/18476.7231

Abstract

INTRODUCTION: Haemodialysis is one of the most conventional treatments of chronic renal failure. The risk of clot formation is high during haemodialysis due to regular contact of blood with the surfaces of foreign objects such as catheters, dialyzers' membrane, and other materials used for dialysis. Therefore, to prevent clot formation during haemodialysis, the dialysis system requires anticoagulation; this is usually done by heparin.

AIM: The present study aimed to compare two heparinization methods and determine the proper impacts of these methods.

MATERIALS AND METHODS: In this quasi-experimental study, 80 haemodialysis patients covered by the dialysis center of Amir-al-momenin Hospital of Zabol were studied in two 40-member groups of heparin therapy methods of bolus injection and continuous infusion. PT and PTT were measured in blood samples collected from all patients before starting haemodialysis. The first group received 3000 units of heparin once the haemodialysis machine started to work and 2000 units of heparin two hours later as bolus injection. In the second group, 1500 units of heparin was injected at the start of dialysis after then, 5000 units of heparin (one mL) were mixed with 11 mL of distilled water and infused using a heparin injection pump up to half an hour before the end of dialysis. At 30 minutes after starting dialysis and at the end of 4 hours of haemodialysis, PT and PTT were measured and compared between the two groups.

RESULTS: According to the results, the mean partial thromboplastin time in the bolus and continuous heparin-receiving group was 41.75±6.29 and 37.90±4.77, respectively, which was statistically significant (p=0.036). But PT was 14.45±1.82 in the bolus heparin group and 13.95±1.39 in the continuous heparin group, which was not significant according to the results of independent t-test (p=0.336).

CONCLUSION: The results indicated a statistically significant difference between the bolus heparin injection and the continuous heparin infusion groups in terms of coagulation tests in haemodialysis patients (p=0.036). Therefore, given the effects of heparin on coagulation, it was more effective in the bolus heparin group than the continuous infusion group. It is recommended to use the bolus method for heparin therapy during haemodialysis.

Keywords: Continuous heparin infusion; Heparin bolus injection; PT; PTT

References

  1. Intensive Care Med. 2007 Sep;33(9):1563-70 - PubMed
  2. Nephrol Dial Transplant. 2003 Nov;18(11):2348-53 - PubMed
  3. Nephrol Dial Transplant. 2001 May;16(5):987-93 - PubMed
  4. J Thromb Thrombolysis. 2014 Nov;38(4):485-92 - PubMed
  5. Blood Coagul Fibrinolysis. 2009 Jan;20(1):57-62 - PubMed
  6. Adv Ren Replace Ther. 1995 Oct;2(4):362-70 - PubMed
  7. EDTNA ERCA J. 2000 Jan-Mar;26(1):20-1 - PubMed
  8. Semin Dial. 2010 Sep-Oct;23(5):510-5 - PubMed
  9. Br J Haematol. 2003 May;121(4):535-55 - PubMed
  10. Chest. 2004 Sep;126(3 Suppl):311S-337S - PubMed
  11. Crit Care. 2004 Aug;8(4):R204-12 - PubMed
  12. Kidney Blood Press Res. 2004;27(4):211-7 - PubMed
  13. Kidney Int. 1999 Oct;56(4):1578-83 - PubMed
  14. Nephrol Dial Transplant. 1999 Nov;14(11):2698-703 - PubMed
  15. J Clin Diagn Res. 2015 Dec;9(12):DC13-5 - PubMed
  16. Thromb J. 2005 Oct 04;3:14 - PubMed
  17. Semin Dial. 2012 Mar-Apr;25(2):233-8 - PubMed
  18. J Thromb Haemost. 2003 Jul;1(7):1471-8 - PubMed
  19. Circulation. 2004 Nov 2;110(18):e454-8 - PubMed

Publication Types