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Kaneai N, Sumitani K, Fukui K, et al. Tocotrienol improves learning and memory deficit of aged rats. J Clin Biochem Nutr. 2016;58(2):114-21doi: 10.3164/jcbn.15-52.
Kaneai, N., Sumitani, K., Fukui, K., Koike, T., Takatsu, H., & Urano, S. (2016). Tocotrienol improves learning and memory deficit of aged rats. Journal of clinical biochemistry and nutrition, 58(2), 114-21. https://doi.org/10.3164/jcbn.15-52
Kaneai, Nozomi, et al. "Tocotrienol improves learning and memory deficit of aged rats." Journal of clinical biochemistry and nutrition vol. 58,2 (2016): 114-21. doi: https://doi.org/10.3164/jcbn.15-52
Kaneai N, Sumitani K, Fukui K, Koike T, Takatsu H, Urano S. Tocotrienol improves learning and memory deficit of aged rats. J Clin Biochem Nutr. 2016 Mar;58(2):114-21. doi: 10.3164/jcbn.15-52. Epub 2016 Feb 05. PMID: 27013777; PMCID: PMC4788404.
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J Clin Biochem Nutr. 2016 Mar;58(2):114-21. doi: 10.3164/jcbn.15-52. Epub 2016 Feb 05.

Tocotrienol improves learning and memory deficit of aged rats.

Journal of clinical biochemistry and nutrition

Nozomi Kaneai, Kazumi Sumitani, Koji Fukui, Taisuke Koike, Hirokatsu Takatsu, Shiro Urano

Affiliations

  1. Life Support Technology Research Center, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama-shi, Saitama 337-8570 Japan.
  2. Department of Bioscience and Engineering, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama-shi, Saitama 337-8570 Japan.
  3. Eisai Food & Chemical Co., LTD., 2-13-10 Nihonbashi, Chuo-ku, Tokyo 103-0027 Japan.
  4. School of Creative Science and Engineering, Faculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555 Japan.

PMID: 27013777 PMCID: PMC4788404 DOI: 10.3164/jcbn.15-52

Abstract

To define whether tocotrienol (T-3) improves cognitive deficit during aging, effect of T-3 on learning and memory functions of aged rats was assessed. It was found that T-3 markedly counteracts the decline in learning and memory function in aged rats. Quantitative analysis of T-3 content in the rat brain showed that the aged rats fed T-3 mixture-supplemented diet revealed the transport of α- and γ-T-3 to the brain. In contrast, normal young rats fed the same diet did not exhibit brain localization. Furthermore, the T-3 inhibited age-related decreases in the expression of certain blood brain barrier (BBB) proteins, including caludin-5, occludin and junctional adhesion molecule (JAM). It was found that the activation of the cellular proto-oncogene c-Src and extracellular signal-regulated protein kinase (ERK), in the mitogen-activated protein kinase (MAPK) cell signaling pathway for neuronal cell death, was markedly inhibited by T-3. These results may reveal that aging induces partial BBB disruption caused by oxidative stress, thereby enabling the transport of T-3 through the BBB to the central nervous system, whereupon neuronal protection may be mediated by inhibition of c-Src and/or ERK activation, resulting in an improvement in age-related cognitive deficits.

Keywords: BBB; aging; c-Src; cognitive deficit; tocotrienol

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