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Malik S, Krishnaprasad K. Natural Micronized Progesterone Sustained Release (SR) and Luteal Phase: Role Redefined!!. J Clin Diagn Res. 2016;10(2):QE01-4doi: 10.7860/JCDR/2016/17278.7212.
Malik, S., & Krishnaprasad, K. (2016). Natural Micronized Progesterone Sustained Release (SR) and Luteal Phase: Role Redefined!!. Journal of clinical and diagnostic research : JCDR, 10(2), QE01-4. https://doi.org/10.7860/JCDR/2016/17278.7212
Malik, Sonia, and Krishnaprasad, Korukonda. "Natural Micronized Progesterone Sustained Release (SR) and Luteal Phase: Role Redefined!!." Journal of clinical and diagnostic research : JCDR vol. 10,2 (2016): QE01-4. doi: https://doi.org/10.7860/JCDR/2016/17278.7212
Malik S, Krishnaprasad K. Natural Micronized Progesterone Sustained Release (SR) and Luteal Phase: Role Redefined!!. J Clin Diagn Res. 2016 Feb;10(2):QE01-4. doi: 10.7860/JCDR/2016/17278.7212. Epub 2016 Feb 01. PMID: 27042538; PMCID: PMC4800604.
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J Clin Diagn Res. 2016 Feb;10(2):QE01-4. doi: 10.7860/JCDR/2016/17278.7212. Epub 2016 Feb 01.

Natural Micronized Progesterone Sustained Release (SR) and Luteal Phase: Role Redefined!!.

Journal of clinical and diagnostic research : JCDR

Sonia Malik, Korukonda Krishnaprasad

Affiliations

  1. Chairperson, FOGSI Infertility Committee , New Delhi, India .
  2. Consultant Gynaecologist, Chembur, Mumbai, India .

PMID: 27042538 PMCID: PMC4800604 DOI: 10.7860/JCDR/2016/17278.7212

Abstract

Role of progesterone in reproductive medicine is evolving with its suggested clinical role for the hormonal and nonhormonal actions in reproductive medicine. The main function of progesterone is to induce 'secretory' changes in endometrium that is further complimented by its immunomodulatory and anti-inflammatory actions. It positively modulates PIBF, NK cells and HOXA 10 genes for better implantation. MHRA recommends Serum Progesterone levels ≥14ng/ml in the mid-luteal phase for supporting pregnancy adequately. Oral Natural Micronized Progesterone SR formulation represents a therapeutic advance in this direction offering 'therapeutic compliance' with oral formulation while avoiding the local side effects related to long-term patient compliance in reproductive disorders. The formulation offers round the clock efficiency and efficacy with single dose administration thereby improving patient convenience and compliance. This formulation has been marketed globally since 1986 utilizing the well validated drug delivery system involving Methylcellulose base. The clinical utility of this formulation is further suggested especially in various conditions related with luteal phase insufficiency and Bad obstetric history (BOH) or luteal phase support in ART. The level of evidence has been quite robust with several clinical studies including Prescription Event Monitoring and Investigator initiated studies supporting the clinical role of oral NMP SR formulation especially in 'Real world' clinic settings for Luteal phase insufficiency that may be physiological or iatrogenic.

Keywords: Bad obstetric history; Luteal phase support; Prescription event monitoring

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