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Slopien A, Rybakowski F, Dmitrzak-Weglarz M, et al. TNF-α and intPLA2 genes' polymorphism in anorexia nervosa. Acta Neuropsychiatr. 2004;16(6):290-4doi: 10.1111/j.0924-2708.2004.00104.x.
Slopien, A., Rybakowski, F., Dmitrzak-Weglarz, M., Czerski, P., Hauser, J., Komorowska-Pietrzykowska, R., & Rajewski, A. (2004). TNF-α and intPLA2 genes' polymorphism in anorexia nervosa. Acta neuropsychiatrica, 16(6), 290-4. https://doi.org/10.1111/j.0924-2708.2004.00104.x
Slopien, Agnieszka, et al. "TNF-α and intPLA2 genes' polymorphism in anorexia nervosa." Acta neuropsychiatrica vol. 16,6 (2004): 290-4. doi: https://doi.org/10.1111/j.0924-2708.2004.00104.x
Slopien A, Rybakowski F, Dmitrzak-Weglarz M, Czerski P, Hauser J, Komorowska-Pietrzykowska R, Rajewski A. TNF-α and intPLA2 genes' polymorphism in anorexia nervosa. Acta Neuropsychiatr. 2004 Dec;16(6):290-4. doi: 10.1111/j.0924-2708.2004.00104.x. PMID: 26984541.
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Acta Neuropsychiatr. 2004 Dec;16(6):290-4. doi: 10.1111/j.0924-2708.2004.00104.x.

TNF-α and intPLA2 genes' polymorphism in anorexia nervosa.

Acta neuropsychiatrica

Agnieszka Slopien, Filip Rybakowski, Monika Dmitrzak-Weglarz, Piotr Czerski, Joanna Hauser, Renata Komorowska-Pietrzykowska, Andrzej Rajewski

Affiliations

  1. 1Department of Child and Adolescent Psychiatry, University of Medical Sciences, Poznañ, Poland.
  2. 2Department of Adult Psychiatry, University of Medical Sciences, Poznañ, Poland.

PMID: 26984541 DOI: 10.1111/j.0924-2708.2004.00104.x

Abstract

OBJECTIVE: The aim of this study was the assessment of -308G/A tumor necrosis factor (TNF)-α gene polymorphism and intPLA2 gene polymorphism in patients with anorexia nervosa (AN) and healthy controls.

SUBJECTS: We studied 91 non-related patients with AN and 144 healthy women (blood donors and students). The mean age of women from study group was 18.22 years (SD ± 3.13 years) and from control group was 31.71 years (SD ± 8.22).

METHODS: Gene polymorphisms were studied with the use of polymerase chain reaction-restriction fragment length polymorphism method. TNF-α gene polymorphism consists of G/A substitution in -308 promoter region. IntPLA2 gene polymorphism is related to intron 1, in which restrictive region is found and recognized by BanI enzyme.

RESULTS: We did not obtain statistically significant differences in the frequency of genotypes and alleles of -308G/A TNF-α polymorphism between the study and control groups (genotypes: P = 0.106, alleles: P = 0.076). We did analogous analysis in the restrictive and bulimic subgroups. We did not observe statistically relevant differences in the frequency of genotypes (P = 0.700) and alleles (P = 0.305). We did not obtain statistically relevant difference in the frequency of genotypes and alleles of intPLA2 gene between the study group and controls (genotypes: P = 0.300, alleles: P = 0.331). We did analogous analysis in both subgroups of AN. We did not observe statistically relevant differences in the frequency of genotypes (P = 0.344) and alleles (P = 0.230).

CONCLUSIONS: There was no statistically relevant trend for the association between TNF-α polymorphism and AN. We did not find association between studied polymorphism of intPLA2 gene and risk of AN.

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