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Crupi R, Impellizzeri D, Bruschetta G, et al. Co-Ultramicronized Palmitoylethanolamide/Luteolin Promotes Neuronal Regeneration after Spinal Cord Injury. Front Pharmacol. 2016;7:47doi: 10.3389/fphar.2016.00047.
Crupi, R., Impellizzeri, D., Bruschetta, G., Cordaro, M., Paterniti, I., Siracusa, R., Cuzzocrea, S., & Esposito, E. (2016). Co-Ultramicronized Palmitoylethanolamide/Luteolin Promotes Neuronal Regeneration after Spinal Cord Injury. Frontiers in pharmacology, 747. https://doi.org/10.3389/fphar.2016.00047
Crupi, Rosalia, et al. "Co-Ultramicronized Palmitoylethanolamide/Luteolin Promotes Neuronal Regeneration after Spinal Cord Injury." Frontiers in pharmacology vol. 7 (2016): 47. doi: https://doi.org/10.3389/fphar.2016.00047
Crupi R, Impellizzeri D, Bruschetta G, Cordaro M, Paterniti I, Siracusa R, Cuzzocrea S, Esposito E. Co-Ultramicronized Palmitoylethanolamide/Luteolin Promotes Neuronal Regeneration after Spinal Cord Injury. Front Pharmacol. 2016 Mar 08;7:47. doi: 10.3389/fphar.2016.00047. eCollection 2016. PMID: 27014061; PMCID: PMC4782663.
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Front Pharmacol. 2016 Mar 08;7:47. doi: 10.3389/fphar.2016.00047. eCollection 2016.

Co-Ultramicronized Palmitoylethanolamide/Luteolin Promotes Neuronal Regeneration after Spinal Cord Injury.

Frontiers in pharmacology

Rosalia Crupi, Daniela Impellizzeri, Giuseppe Bruschetta, Marika Cordaro, Irene Paterniti, Rosalba Siracusa, Salvatore Cuzzocrea, Emanuela Esposito

Affiliations

  1. Department of Biological and Environmental Sciences, University of Messina Messina, Italy.
  2. Department of Biological and Environmental Sciences, University of MessinaMessina, Italy; Manchester Biomedical Research Centre, Manchester Royal Infirmary, School of Medicine, The University of ManchesterManchester, UK.

PMID: 27014061 PMCID: PMC4782663 DOI: 10.3389/fphar.2016.00047

Abstract

Spinal cord injury (SCI) stimulates activation of astrocytes and infiltration of immune cells at the lesion site; however, the mechanism that promotes the birth of new neurons is still under debate. Neuronal regeneration is restricted after spinal cord injury, but can be stimulated by experimental intervention. Previously we demonstrated that treatment co-ultramicronized palmitoylethanolamide and luteolin, namely co-ultraPEALut, reduced inflammation. The present study was designed to explore the neuroregenerative properties of co-ultraPEALut in an estabished murine model of SCI. A vascular clip was applied to the spinal cord dura at T5-T8 to provoke injury. Mice were treated with co-ultraPEALut (1 mg/kg, intraperitoneally) daily for 72 h after SCI. Co-ultraPEALut increased the numbers of both bromodeoxyuridine-positive nuclei and doublecortin-immunoreactive cells in the spinal cord of injured mice. To correlate neuronal development with synaptic plasticity a Golgi method was employed to analyze dendritic spine density. Co-ultraPEALut administration stimulated expression of the neurotrophic factors brain-derived neurotrophic factor, glial cell-derived neurotrophic factor, nerve growth factor, and neurotrophin-3. These findings show a prominent effect of co-ultraPEALut administration in the management of survival and differentiation of new neurons and spine maturation, and may represent a therapeutic treatment for spinal cord and other traumatic diseases.

Keywords: luteolin; neurogenesis; palmitoylethanolamide; regeneration; spinal cord injury

References

  1. J Urol. 2009 Nov;182(5):2504-10 - PubMed
  2. Neurosci Lett. 2006 Jan 30;393(2-3):141-6 - PubMed
  3. Eur J Neurosci. 2003 Feb;17(4):782-90 - PubMed
  4. J Neurotrauma. 2006 May;23(5):635-59 - PubMed
  5. Science. 2007 May 25;316(5828):1212-6 - PubMed
  6. PLoS One. 2011;6(9):e24636 - PubMed
  7. J Agric Food Chem. 2007 Feb 21;55(4):1321-6 - PubMed
  8. J Pharmacol Exp Ther. 2006 Mar;316(3):1006-16 - PubMed
  9. Life Sci. 2005 Aug 19;77(14):1685-98 - PubMed
  10. Curr Med Chem. 2002 Mar;9(6):663-74 - PubMed
  11. Brain. 2009 Nov;132(Pt 11):2909-21 - PubMed
  12. Brain Res. 2006 Dec 18;1126(1):176-82 - PubMed
  13. Am J Psychiatry. 2003 Jan;160(1):149-55 - PubMed
  14. Neuroscientist. 2009 Apr;15(2):149-65 - PubMed
  15. Life Sci. 1998;63(8):PL125-9 - PubMed
  16. Stroke. 2007 Nov;38(11):3032-9 - PubMed
  17. Mol Cell Biol. 1994 Jan;14(1):759-67 - PubMed
  18. Biotechniques. 1994 Jun;16(6):1126-8 - PubMed
  19. Neuroscience. 2005;130(1):75-90 - PubMed
  20. J Pharmacol Exp Ther. 2006 Oct;319(1):127-38 - PubMed
  21. CNS Neurol Disord Drug Targets. 2013 Nov;12(7):989-1001 - PubMed
  22. Ann Emerg Med. 1993 Jun;22(6):987-92 - PubMed
  23. J Neurotrauma. 2012 Apr 10;29(6):1266-76 - PubMed
  24. Neurochem Int. 2010 Sep;57(2):143-52 - PubMed
  25. Brain. 2011 Jun;134(Pt 6):1610-22 - PubMed
  26. Eur J Neurosci. 2011 Apr;33(8):1411-20 - PubMed
  27. Development. 1995 Aug;121(8):2461-70 - PubMed
  28. Proc Natl Acad Sci U S A. 1989 Jun;86(11):4127-31 - PubMed
  29. Spine (Phila Pa 1976). 2012 Dec 15;37(26):2125-35 - PubMed
  30. Curr Opin Genet Dev. 2003 Oct;13(5):543-50 - PubMed
  31. Neurobiol Dis. 2010 Feb;37(2):267-74 - PubMed
  32. Neuroscience. 1983 Oct;10(2):521-43 - PubMed
  33. PLoS Biol. 2008 Jul 22;6(7):e182 - PubMed
  34. Mol Cell Neurosci. 2008 Aug;38(4):526-36 - PubMed
  35. Glia. 2005 May;50(3):247-57 - PubMed
  36. J Neurosci. 2010 Jun 23;30(25):8613-23 - PubMed
  37. J Neurosurg. 1998 Nov;89(5):699-706 - PubMed
  38. Asia Pac J Public Health. 2010 Jan;22(1):9-18 - PubMed
  39. Expert Opin Ther Targets. 2004 Oct;8(5):391-9 - PubMed
  40. Eur J Pharmacol. 2010 Feb 10;627(1-3):99-105 - PubMed
  41. J Neurosci. 2000 Dec 15;20(24):9104-10 - PubMed
  42. Neurosci Bull. 2013 Aug;29(4):509-16 - PubMed
  43. Neuroscientist. 2009 Oct;15(5):436-44 - PubMed
  44. J Neurosci. 2002 Mar 1;22(5):1784-93 - PubMed
  45. Auton Neurosci. 2006 Jun 30;126-127:50-8 - PubMed
  46. J Neurosci. 2009 Apr 1;29(13):4172-88 - PubMed
  47. J Neurosci. 2002 Feb 1;22(3):629-34 - PubMed
  48. Brain Behav Immun. 2012 Nov;26(8):1310-21 - PubMed
  49. J Neurotrauma. 2011 Dec;28(12):2417-27 - PubMed
  50. Curr Pharm Des. 2014;20(13):2218-30 - PubMed
  51. Brain. 2012 Nov;135(Pt 11):3320-35 - PubMed
  52. J Neurosci. 2006 Apr 26;26(17):4672-80 - PubMed
  53. Nat Rev Neurosci. 2007 Jun;8(6):481-8 - PubMed
  54. Spine J. 2004 Jul-Aug;4(4):373-8 - PubMed
  55. Stem Cells. 2006 Mar;24(3):739-47 - PubMed
  56. Brain Behav Immun. 2011 Aug;25(6):1099-112 - PubMed
  57. J Pharmacol Exp Ther. 2008 Jul;326(1):12-23 - PubMed
  58. Pharmacol Rev. 2001 Mar;53(1):135-59 - PubMed
  59. Brain. 2009 Aug;132(Pt 8):2206-18 - PubMed
  60. J Neuroinflammation. 2013 Jul 23;10 :91 - PubMed
  61. Brain Res Brain Res Rev. 2002 Jun;39(1):55-73 - PubMed
  62. PLoS One. 2008 Mar 05;3(3):e1707 - PubMed
  63. J Neuroinflammation. 2013 Feb 01;10:20 - PubMed

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