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Kremer R, Gilsanz V. Fat and Bone: An Odd Couple. Front Endocrinol (Lausanne). 2016;6:190doi: 10.3389/fendo.2015.00190.
Kremer, R., & Gilsanz, V. (2015). Fat and Bone: An Odd Couple. Frontiers in endocrinology, 6190. https://doi.org/10.3389/fendo.2015.00190
Kremer, Richard, and Gilsanz, Vicente. "Fat and Bone: An Odd Couple." Frontiers in endocrinology vol. 6 (2015): 190. doi: https://doi.org/10.3389/fendo.2015.00190
Kremer R, Gilsanz V. Fat and Bone: An Odd Couple. Front Endocrinol (Lausanne). 2016 Mar 07;6:190. doi: 10.3389/fendo.2015.00190. eCollection 2015. PMID: 27014187; PMCID: PMC4779997.
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Front Endocrinol (Lausanne). 2016 Mar 07;6:190. doi: 10.3389/fendo.2015.00190. eCollection 2015.

Fat and Bone: An Odd Couple.

Frontiers in endocrinology

Richard Kremer, Vicente Gilsanz

Affiliations

  1. McGill University , Montreal, QC , Canada.
  2. Children's Hospital Los Angeles, Keck School of Medicine of the University of Southern California , Los Angeles, CA , USA.

PMID: 27014187 PMCID: PMC4779997 DOI: 10.3389/fendo.2015.00190

Abstract

In this review, we will first discuss the concept of bone strength and introduce how fat at different locations, including the bone marrow, directly or indirectly regulates bone turnover. We will then review the current literature supporting the mechanistic relationship between marrow fat and bone and our understanding of the relationship between body fat, body weight, and bone with emphasis on its hormonal regulation. Finally, we will briefly discuss the importance and challenges of accurately measuring the fat compartments using non-invasive methods. This review highlights the complex relationship between fat and bone and how these new concepts will impact our diagnostic and therapeutic approaches in the very near future.

Keywords: MRI; bone; fat; hormones; imaging; marrow fat; vitamin D

References

  1. Endocrinology. 2002 Oct;143(10):4065-73 - PubMed
  2. Arch Dis Child. 2004 Feb;89(2):197-9 - PubMed
  3. Endocrinology. 1989 Feb;124(2):701-6 - PubMed
  4. Int J Body Compos Res. 2009 Jul 1;7(1):37-40 - PubMed
  5. J Magn Reson Imaging. 2007 Mar;25(3):644-52 - PubMed
  6. Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E987-98 - PubMed
  7. J Clin Endocrinol Metab. 2011 Mar;96(3):782-6 - PubMed
  8. N Engl J Med. 2007 Jul 19;357(3):266-81 - PubMed
  9. Stem Cells. 2009 Mar;27(3):550-8 - PubMed
  10. Am J Manag Care. 2011 May;17 Suppl 6:S164-9 - PubMed
  11. Bone. 1996 Nov;19(5):421-8 - PubMed
  12. Acad Radiol. 2005 May;12(5):636-9 - PubMed
  13. J Cell Biochem. 2000 Sep 14;79(4):557-65 - PubMed
  14. Bone. 2014 Jan;58:55-8 - PubMed
  15. J Biol Chem. 2003 Nov 14;278(46):45969-77 - PubMed
  16. Bone. 2005 Oct;37(4):474-81 - PubMed
  17. J Biomech. 1994 Mar;27(3):339-60 - PubMed
  18. Magn Reson Med. 2010 Feb;63(2):494-501 - PubMed
  19. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3324-9 - PubMed
  20. Med Clin North Am. 2003 Sep;87(5):1039-63 - PubMed
  21. J Am Geriatr Soc. 1999 Oct;47(10):1195-201 - PubMed
  22. J Clin Endocrinol Metab. 2003 Jan;88(1):157-61 - PubMed
  23. Cell. 2002 Nov 1;111(3):305-17 - PubMed
  24. J Bone Miner Metab. 2005;23(4):275-9 - PubMed
  25. Calcif Tissue Int. 2009 Jun;84(6):453-61 - PubMed
  26. J Cell Biochem Suppl. 1998;30-31:73-82 - PubMed
  27. AJNR Am J Neuroradiol. 2001 Sep;22(8):1620-7 - PubMed
  28. J Biomech. 1995 Nov;28(11):1281-97 - PubMed
  29. Bone. 2002 May;30(5):685-91 - PubMed
  30. J Nutr. 2003 Jan;133(1):102-6 - PubMed
  31. Radiology. 2000 Nov;217(2):527-38 - PubMed
  32. J Appl Physiol (1985). 1998 Nov;85(5):1778-85 - PubMed
  33. Biochem J. 2003 Dec 15;376(Pt 3):607-13 - PubMed
  34. Med Hypotheses. 2001 Jun;56(6):702-8 - PubMed
  35. Bone. 2002 Nov;31(5):547-55 - PubMed
  36. Endocrinology. 2001 Aug;142(8):3546-53 - PubMed
  37. Magn Reson Med. 2005 Sep;54(3):636-44 - PubMed
  38. Clin Nutr. 2007 Oct;26(5):573-80 - PubMed
  39. Osteoporos Int. 2005 Jan;16(1):101-8 - PubMed
  40. Am J Clin Pathol. 1965 Apr;43:326-31 - PubMed
  41. Calcif Tissue Int. 2000 Jan;66(1):47-52 - PubMed
  42. Endocr Rev. 2000 Apr;21(2):115-37 - PubMed
  43. Endocrinology. 1986 Oct;119(4):1786-92 - PubMed
  44. J Bone Miner Res. 2005 Apr;20(4):613-8 - PubMed
  45. Am J Physiol Endocrinol Metab. 2005 Apr;288(4):E723-30 - PubMed
  46. Arch Phys Med Rehabil. 1999 Jan;80(1):54-8 - PubMed
  47. Cerebrovasc Dis. 2005;20(3):187-92 - PubMed
  48. Int J Clin Pract. 2003 May;57(4):258-61 - PubMed
  49. NIH Consens Statement. 2000 Mar 27-29;17(1):1-45 - PubMed
  50. J Cell Biochem. 2002;85(4):825-36 - PubMed
  51. Bone. 2003 Oct;33(4):646-51 - PubMed
  52. Nat Clin Pract Endocrinol Metab. 2006 Jun;2(6):318-27 - PubMed
  53. Osteoporos Int. 2006;17(3):426-32 - PubMed
  54. J Clin Endocrinol Metab. 2012 Apr;97(4):E584-90 - PubMed
  55. Exp Gerontol. 2004 Mar;39(3):333-8 - PubMed
  56. Eur J Intern Med. 2013 Oct;24(7):644-9 - PubMed
  57. Pediatrics. 2003 Dec;112(6 Pt 1):e447 - PubMed
  58. Exp Gerontol. 2000 Oct;35(8):1061-74 - PubMed
  59. Bone. 2004 Oct;35(4):842-9 - PubMed
  60. Am J Clin Nutr. 2000 Sep;72(3):690-3 - PubMed
  61. Eur J Radiol. 1998 Jan;26(2):177-82 - PubMed
  62. J Clin Endocrinol Metab. 2007 Nov;92 (11):4248-53 - PubMed
  63. Nature. 2000 Nov 30;408(6812):600-5 - PubMed
  64. J Cell Physiol. 1992 May;151(2):215-27 - PubMed
  65. Med Image Comput Comput Assist Interv. 2008;11(Pt 1):119-26 - PubMed
  66. BMJ. 2009 Oct 01;339:b3692 - PubMed
  67. Osteoporos Int. 2005 Nov;16(11):1330-8 - PubMed
  68. Endocrinology. 1999 Nov;140(11):5036-44 - PubMed
  69. J Bone Miner Res. 2000 Jun;15(6):1113-8 - PubMed
  70. J Bone Miner Res. 2003 Feb;18(2):352-9 - PubMed
  71. Biogerontology. 2001;2(3):165-71 - PubMed
  72. J Clin Endocrinol Metab. 2007 Mar;92(3):938-41 - PubMed
  73. J Biol Chem. 2014 Jun 13;289(24):16699-710 - PubMed
  74. Radiology. 1994 Sep;192(3):845-50 - PubMed
  75. J Clin Endocrinol Metab. 2004 Mar;89(3):1196-9 - PubMed
  76. J Bone Miner Res. 2004 Feb;19(2):256-64 - PubMed
  77. Calcif Tissue Int. 2000 Jun;66(6):419-24 - PubMed
  78. Bone. 2002 Jan;30(1):307-13 - PubMed
  79. Br J Nutr. 2009 Mar;101(5):659-63 - PubMed
  80. JAMA. 1993 Dec 22-29;270(24):2926-7 - PubMed
  81. Am J Med. 1997 Oct;103(4):274-80 - PubMed
  82. Nature. 2002 Jul 4;418(6893):41-9 - PubMed
  83. Endocrinol Jpn. 1979 Jun;26(Suppl):65-72 - PubMed
  84. Calcif Tissue Int. 1996 Dec;59(6):492-5 - PubMed
  85. Biomed Res Int. 2015;2015:801518 - PubMed
  86. Obesity (Silver Spring). 2006 Feb;14 Suppl 1:16S-19S - PubMed
  87. Cell. 2000 Jan 21;100(2):197-207 - PubMed
  88. Clin Orthop Relat Res. 1971 Oct;80:147-54 - PubMed
  89. J Bone Miner Res. 2003 Feb;18(2):343-51 - PubMed
  90. Int J Biochem Cell Biol. 2004 Oct;36(10):1910-8 - PubMed
  91. Endocrinology. 2010 Jan;151(1):14-22 - PubMed
  92. J Clin Endocrinol Metab. 2001 May;86(5):1930-5 - PubMed
  93. Aust N Z J Med. 1995 Jun;25(3):218-23 - PubMed
  94. Radiology. 2005 Sep;236(3):945-51 - PubMed
  95. J Clin Pathol. 2008 May;61(5):577-87 - PubMed
  96. J Bone Miner Res. 2004 Feb;19(2):265-9 - PubMed
  97. J Clin Invest. 2004 Mar;113(6):846-55 - PubMed
  98. Nat Cell Biol. 2007 Nov;9(11):1273-85 - PubMed
  99. J Am Geriatr Soc. 1999 Feb;47(2):220-6 - PubMed
  100. J Clin Endocrinol Metab. 2010 Apr;95(4):1595-601 - PubMed
  101. J Clin Endocrinol Metab. 2002 Jul;87(7):3324-9 - PubMed
  102. Osteoporos Int. 2001;12(10):803-10 - PubMed
  103. Endocrinology. 2007 Feb;148(2):903-11 - PubMed
  104. Osteoporos Int. 2002 Oct;13(10):777-87 - PubMed
  105. Am J Epidemiol. 1997 Aug 15;146(4):287-93 - PubMed
  106. J Clin Endocrinol Metab. 2012 Aug;97(8):2693-8 - PubMed
  107. N Engl J Med. 1992 Dec 3;327(23 ):1637-42 - PubMed
  108. J Pediatr. 2001 Oct;139(4):509-15 - PubMed
  109. Bone. 1991;12(2):123-31 - PubMed
  110. Bone. 2005 Apr;36(4):585-98 - PubMed
  111. J Clin Invest. 2003 Dec;112(12):1796-808 - PubMed
  112. Clin Sci (Lond). 1979 Feb;56(2):157-61 - PubMed
  113. J Clin Endocrinol Metab. 2010 Jun;95(6):2977-82 - PubMed
  114. Exp Cell Res. 2003 Aug 1;288(1):168-76 - PubMed
  115. Transl Res. 2009 Jan;153(1):11-6 - PubMed
  116. Acta Med Scand. 1987;222(4):361-7 - PubMed
  117. J Clin Endocrinol Metab. 2009 Sep;94(9):3387-93 - PubMed
  118. JAMA. 2005 May 11;293(18):2257-64 - PubMed
  119. J Clin Endocrinol Metab. 2007 Apr;92(4):1517-23 - PubMed
  120. Osteoporos Int. 1998;8(3):247-54 - PubMed
  121. Osteoporos Int. 2008 Oct;19(10 ):1395-408 - PubMed
  122. Curr Opin Rheumatol. 2004 Jul;16(4):464-8 - PubMed
  123. J Biol Chem. 2000 May 26;275(21):16134-8 - PubMed
  124. J Clin Endocrinol Metab. 2009 Feb;94(2):559-63 - PubMed
  125. Am J Physiol Endocrinol Metab. 2007 Aug;293(2):E444-52 - PubMed
  126. Obesity (Silver Spring). 2010 Apr;18(4):841-7 - PubMed
  127. J Bone Miner Res. 2003 Dec;18(12):2180-9 - PubMed
  128. Nat Med. 2001 Aug;7(8):947-53 - PubMed
  129. Biochem Biophys Res Commun. 2003 Dec 12;312(2):513-9 - PubMed
  130. J Biomech Eng. 2003 Feb;125(1):25-37 - PubMed
  131. Bone. 2006 Mar;38(3):317-21 - PubMed
  132. Arch Biochem Biophys. 2008 May 15;473(2):112-6 - PubMed
  133. J Clin Endocrinol Metab. 2005 Mar;90(3):1525-30 - PubMed
  134. Arch Dis Child. 2004 Aug;89(8):781-4 - PubMed
  135. FASEB J. 1990 Aug;4(11):2890-8 - PubMed
  136. N Engl J Med. 1997 Sep 4;337(10):670-6 - PubMed
  137. Endocr Rev. 1986 Nov;7(4):434-48 - PubMed
  138. Diabetes Care. 2005 May;28(5):1228-30 - PubMed
  139. J Bone Miner Res. 2010 Mar;25(3):513-9 - PubMed
  140. Horm Metab Res. 1999 Apr;31(4):271-3 - PubMed
  141. Nature. 2005 Mar 24;434(7032):514-20 - PubMed
  142. Endocrinology. 2004 Jan;145(1):401-6 - PubMed
  143. Exp Hematol. 1989 Jan;17(1):34-7 - PubMed
  144. Nutr J. 2012 Sep 22;11:78 - PubMed
  145. Am J Clin Nutr. 2001 Feb;73(2):347-52 - PubMed
  146. J Clin Endocrinol Metab. 2008 Jun;93(6):2281-6 - PubMed
  147. J Clin Pathol. 2002 Sep;55(9):693-8 - PubMed
  148. Biochem Biophys Res Commun. 2005 Apr 1;329(1):177-81 - PubMed
  149. J Clin Endocrinol Metab. 2009 Jan;94(1):67-73 - PubMed
  150. Obes Surg. 1993 Nov;3(4):421-424 - PubMed
  151. J Gerontol A Biol Sci Med Sci. 2005 Mar;60(3):324-33 - PubMed
  152. Diabetes Res. 1989 Jul;11(3):141-7 - PubMed
  153. Calcif Tissue Int. 1999 Aug;65(2):173-80 - PubMed
  154. Can J Neurol Sci. 2009 May;36(3):336-9 - PubMed
  155. Front Physiol. 2014 Jun 24;5:228 - PubMed
  156. Am J Clin Nutr. 1990 Jun;51(6):953-7 - PubMed
  157. Pediatr Radiol. 2005 Jun;35(6):601-7 - PubMed
  158. Eur J Endocrinol. 2007 Aug;157(2):225-32 - PubMed
  159. Osteoporos Int. 2008 Sep;19(9):1283-90 - PubMed
  160. Nat Rev Genet. 2002 Aug;3(8):589-600 - PubMed
  161. Am J Clin Nutr. 2007 Feb;85(2):377-84 - PubMed
  162. J Bone Miner Res. 2011 Jul;26(7):1472-83 - PubMed
  163. Pituitary. 2009;12(2):105-15 - PubMed
  164. Magn Reson Med. 2006 Sep;56(3):572-84 - PubMed
  165. J Clin Endocrinol Metab. 2006 Feb;91(2):405-12 - PubMed
  166. J Endocrinol. 2002 Nov;175(2):405-15 - PubMed
  167. Stem Cells. 2012 May;30(5):1042-8 - PubMed
  168. Bone. 2002 Jun;30(6):886-90 - PubMed
  169. Magn Reson Med. 1991 Apr;18(2):371-83 - PubMed
  170. Osteoporos Int. 2007 Nov;18(11):1507-14 - PubMed
  171. Nutr Metab (Lond). 2010 Jul 23;7:62 - PubMed
  172. Calcif Tissue Int. 1997 Aug;61(2):134-8 - PubMed
  173. AJR Am J Roentgenol. 2008 Jan;190(1):W8-12 - PubMed
  174. Obesity (Silver Spring). 2011 Nov;19(11):2228-34 - PubMed
  175. Connect Tissue Res. 2000;41(1):45-56 - PubMed
  176. Br J Nutr. 1991 Mar;65(2):95-103 - PubMed
  177. J Bone Miner Res. 1997 May;12 (5):697-711 - PubMed
  178. J Biol Chem. 2004 Aug 6;279(32):34015-22 - PubMed
  179. J Bone Miner Res. 2002 Feb;17(2):200-9 - PubMed
  180. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9856-60 - PubMed
  181. Mol Cell Endocrinol. 2012 Jan 2;348(1):55-66 - PubMed
  182. Bone. 2005 Dec;37(6):759-69 - PubMed
  183. Endocrinology. 1999 Apr;140(4):1630-8 - PubMed
  184. J Bone Miner Res. 2006 Sep;21(9):1464-74 - PubMed
  185. J Pediatr. 2011 May;158(5):722-6 - PubMed
  186. Br J Nutr. 2008 Aug;100(2):269-72 - PubMed
  187. Am J Clin Nutr. 2007 Jan;85(1):54-9 - PubMed
  188. J Magn Reson Imaging. 1995 Mar-Apr;5(2):181-5 - PubMed
  189. Bone. 2003 Nov;33(5):771-8 - PubMed

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